Antioxidant Properties of 5-ASA: Potential Mechanism for Its Anti-Inflammatory Activity
There is a growing body of experimental data to suggest that the inflamed intestine and/or colon may be subjected to considerable oxidative stress. The most probable source of these oxidants are the phagocytic leukocytes, since these cells are present in large numbers in the inflamed mucosa and are...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/324287 |
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| Summary: | There is a growing body of experimental data to suggest that the
inflamed intestine and/or colon may be subjected to considerable oxidative
stress. The most probable source of these oxidants are the phagocytic
leukocytes, since these cells are present in large numbers in the inflamed mucosa
and are known to produce significant amounts of potentially injurious reactive
oxygen species in response to inflammatory stimuli. The authors' laboratory and
others have demonstrated that 5-aminosalicylic acid (5-ASA) possesses potent
antioxidant activity, including free radical scavenging properties and the ability
to decompose neutrophilic oxidants (eg, hypochlorous acid) and detoxify
hemoprotein-associated oxidizing agents. 5-ASA has the additional property
of being able to chelate iron and render it poorly redox active. Therefore, it is
proposed that much of the anti-inflammatory activity of 5-ASA may be due to
its numerous antioxidant properties. |
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| ISSN: | 0835-7900 |