Outbreak of Norovirus GII.P17-GII.17 in the Canadian Province of Nova Scotia
Background. Norovirus is the leading cause of viral gastroenteritis, with GII.4 being the most common circulating genotype. Recently, outbreaks in China revealed that norovirus GII.17 GII.P17 had become predominant. Objective. This study aimed to characterize the distribution of norovirus genotypes...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2016/1280247 |
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| author | Jason J. LeBlanc Janice Pettipas Daniel Gaston Robin Taylor Todd F. Hatchette Tim F. Booth Russell Mandes Andrew McDermid Elsie Grudeski |
| author_facet | Jason J. LeBlanc Janice Pettipas Daniel Gaston Robin Taylor Todd F. Hatchette Tim F. Booth Russell Mandes Andrew McDermid Elsie Grudeski |
| author_sort | Jason J. LeBlanc |
| collection | DOAJ |
| description | Background. Norovirus is the leading cause of viral gastroenteritis, with GII.4 being the most common circulating genotype. Recently, outbreaks in China revealed that norovirus GII.17 GII.P17 had become predominant. Objective. This study aimed to characterize the distribution of norovirus genotypes circulating in Nova Scotia. Methods. Stool specimens were collected from gastrointestinal outbreaks in Nova Scotia between Jan 2014 and June 2015 and subjected to real-time RT-PCR. Norovirus-positive specimens were referred to the National Microbiology Laboratory for sequence-based genotyping. Results. The first norovirus GII.P17-GII.17 outbreak in Canada was identified, but no widespread activity was observed in Nova Scotia. Discussion. It is unknown whether GII.P17-GII.17 is more widespread in Canada since contributions to Canadian surveillance are too sparse to effectively monitor the epidemiology of emerging norovirus genotypes. Conclusions. Presence of norovirus GII.17:P17 in Canada highlights the need for more systematic surveillance to ensure that molecular targets used for laboratory detection are effective and help understand norovirus evolution, epidemiology, and pathogenesis. |
| format | Article |
| id | doaj-art-cd676c9a385f4ba980160ce5efdfa1d2 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-cd676c9a385f4ba980160ce5efdfa1d22025-02-03T01:21:28ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932016-01-01201610.1155/2016/12802471280247Outbreak of Norovirus GII.P17-GII.17 in the Canadian Province of Nova ScotiaJason J. LeBlanc0Janice Pettipas1Daniel Gaston2Robin Taylor3Todd F. Hatchette4Tim F. Booth5Russell Mandes6Andrew McDermid7Elsie Grudeski8Nova Scotia Health Authority (NSHA), Halifax, NS, B3H 1V8, CanadaNova Scotia Health Authority (NSHA), Halifax, NS, B3H 1V8, CanadaNova Scotia Health Authority (NSHA), Halifax, NS, B3H 1V8, CanadaNova Scotia Health Authority (NSHA), Halifax, NS, B3H 1V8, CanadaNova Scotia Health Authority (NSHA), Halifax, NS, B3H 1V8, CanadaNational Microbiology Laboratory (NML), Winnipeg, MB, R3E 3R2, CanadaNational Microbiology Laboratory (NML), Winnipeg, MB, R3E 3R2, CanadaUniversity of Manitoba, Winnipeg, MB, R3T 2N2, CanadaNational Microbiology Laboratory (NML), Winnipeg, MB, R3E 3R2, CanadaBackground. Norovirus is the leading cause of viral gastroenteritis, with GII.4 being the most common circulating genotype. Recently, outbreaks in China revealed that norovirus GII.17 GII.P17 had become predominant. Objective. This study aimed to characterize the distribution of norovirus genotypes circulating in Nova Scotia. Methods. Stool specimens were collected from gastrointestinal outbreaks in Nova Scotia between Jan 2014 and June 2015 and subjected to real-time RT-PCR. Norovirus-positive specimens were referred to the National Microbiology Laboratory for sequence-based genotyping. Results. The first norovirus GII.P17-GII.17 outbreak in Canada was identified, but no widespread activity was observed in Nova Scotia. Discussion. It is unknown whether GII.P17-GII.17 is more widespread in Canada since contributions to Canadian surveillance are too sparse to effectively monitor the epidemiology of emerging norovirus genotypes. Conclusions. Presence of norovirus GII.17:P17 in Canada highlights the need for more systematic surveillance to ensure that molecular targets used for laboratory detection are effective and help understand norovirus evolution, epidemiology, and pathogenesis.http://dx.doi.org/10.1155/2016/1280247 |
| spellingShingle | Jason J. LeBlanc Janice Pettipas Daniel Gaston Robin Taylor Todd F. Hatchette Tim F. Booth Russell Mandes Andrew McDermid Elsie Grudeski Outbreak of Norovirus GII.P17-GII.17 in the Canadian Province of Nova Scotia Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Outbreak of Norovirus GII.P17-GII.17 in the Canadian Province of Nova Scotia |
| title_full | Outbreak of Norovirus GII.P17-GII.17 in the Canadian Province of Nova Scotia |
| title_fullStr | Outbreak of Norovirus GII.P17-GII.17 in the Canadian Province of Nova Scotia |
| title_full_unstemmed | Outbreak of Norovirus GII.P17-GII.17 in the Canadian Province of Nova Scotia |
| title_short | Outbreak of Norovirus GII.P17-GII.17 in the Canadian Province of Nova Scotia |
| title_sort | outbreak of norovirus gii p17 gii 17 in the canadian province of nova scotia |
| url | http://dx.doi.org/10.1155/2016/1280247 |
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