An Interactive Computational Pipeline to Investigate Ventricular Hemodynamics with Real‐Time Three‐Dimensional Echocardiography and Computational Fluid Dynamics
ABSTRACT Blood flow within the ventricle can provide important information on the performance of the heart. The determined blood flow structures are used to extract flow biomarkers to quantify cardiac function. Patient‐specific computational fluid dynamics (CFD) models that import segmented ventricu...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Engineering Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/eng2.13041 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576648046706688 |
|---|---|
| author | Jan‐Niklas Thiel Daniel Verhülsdonk Ulrich Steinseifer Katharina Linden Ulrike Herberg Ingeborg Friehs Daniel Diaz‐Gil Michael Neidlin |
| author_facet | Jan‐Niklas Thiel Daniel Verhülsdonk Ulrich Steinseifer Katharina Linden Ulrike Herberg Ingeborg Friehs Daniel Diaz‐Gil Michael Neidlin |
| author_sort | Jan‐Niklas Thiel |
| collection | DOAJ |
| description | ABSTRACT Blood flow within the ventricle can provide important information on the performance of the heart. The determined blood flow structures are used to extract flow biomarkers to quantify cardiac function. Patient‐specific computational fluid dynamics (CFD) models that import segmented ventricular deformations from noninvasive imaging data for an individualized hemodynamical analysis are often used. However, tedious preprocessing of those geometries is often necessary and decisions on the modeling of the valve and the surrounding vessels have to be made on an individual level. This leads to a lack of reproducibility and usability of the existing computational models. In this work, we introduce IP‐HEART—an interactive and open‐source computational pipeline to perform geometry processing for CFD models of ventricular blood flow. We showcase its use on real‐time three‐dimensional echocardiography data of three patient datasets from two different clinical centers. We outline how different modeling assumptions of the mitral valve can be implemented and quantify their effect on CFD simulations. The results correspond well with clinical data on transvalvular Doppler ultrasound recordings and distinct flow features such as mitral jet and diastolic vortex formation can be observed. The pipeline is accompanied by an extensive video tutorial and freely available code for further use. |
| format | Article |
| id | doaj-art-cd49a61b73664a8caddf362af6e962fe |
| institution | Kabale University |
| issn | 2577-8196 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Engineering Reports |
| spelling | doaj-art-cd49a61b73664a8caddf362af6e962fe2025-01-31T00:22:48ZengWileyEngineering Reports2577-81962025-01-0171n/an/a10.1002/eng2.13041An Interactive Computational Pipeline to Investigate Ventricular Hemodynamics with Real‐Time Three‐Dimensional Echocardiography and Computational Fluid DynamicsJan‐Niklas Thiel0Daniel Verhülsdonk1Ulrich Steinseifer2Katharina Linden3Ulrike Herberg4Ingeborg Friehs5Daniel Diaz‐Gil6Michael Neidlin7Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty RWTH Aachen University Aachen GermanyDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty RWTH Aachen University Aachen GermanyDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty RWTH Aachen University Aachen GermanyDepartment of Paediatric Cardiology, Medical Faculty University Hospital Aachen Aachen GermanyDepartment of Paediatric Cardiology, Medical Faculty University Hospital Aachen Aachen GermanyDepartment of Cardiac Surgery Boston Children's Hospital Boston Massachusetts USADepartment of Cardiac Surgery Boston Children's Hospital Boston Massachusetts USADepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty RWTH Aachen University Aachen GermanyABSTRACT Blood flow within the ventricle can provide important information on the performance of the heart. The determined blood flow structures are used to extract flow biomarkers to quantify cardiac function. Patient‐specific computational fluid dynamics (CFD) models that import segmented ventricular deformations from noninvasive imaging data for an individualized hemodynamical analysis are often used. However, tedious preprocessing of those geometries is often necessary and decisions on the modeling of the valve and the surrounding vessels have to be made on an individual level. This leads to a lack of reproducibility and usability of the existing computational models. In this work, we introduce IP‐HEART—an interactive and open‐source computational pipeline to perform geometry processing for CFD models of ventricular blood flow. We showcase its use on real‐time three‐dimensional echocardiography data of three patient datasets from two different clinical centers. We outline how different modeling assumptions of the mitral valve can be implemented and quantify their effect on CFD simulations. The results correspond well with clinical data on transvalvular Doppler ultrasound recordings and distinct flow features such as mitral jet and diastolic vortex formation can be observed. The pipeline is accompanied by an extensive video tutorial and freely available code for further use.https://doi.org/10.1002/eng2.13041geometry processingmoving mesh simulationsreal‐time three‐dimensional echocardiographyventricular hemodynamics |
| spellingShingle | Jan‐Niklas Thiel Daniel Verhülsdonk Ulrich Steinseifer Katharina Linden Ulrike Herberg Ingeborg Friehs Daniel Diaz‐Gil Michael Neidlin An Interactive Computational Pipeline to Investigate Ventricular Hemodynamics with Real‐Time Three‐Dimensional Echocardiography and Computational Fluid Dynamics Engineering Reports geometry processing moving mesh simulations real‐time three‐dimensional echocardiography ventricular hemodynamics |
| title | An Interactive Computational Pipeline to Investigate Ventricular Hemodynamics with Real‐Time Three‐Dimensional Echocardiography and Computational Fluid Dynamics |
| title_full | An Interactive Computational Pipeline to Investigate Ventricular Hemodynamics with Real‐Time Three‐Dimensional Echocardiography and Computational Fluid Dynamics |
| title_fullStr | An Interactive Computational Pipeline to Investigate Ventricular Hemodynamics with Real‐Time Three‐Dimensional Echocardiography and Computational Fluid Dynamics |
| title_full_unstemmed | An Interactive Computational Pipeline to Investigate Ventricular Hemodynamics with Real‐Time Three‐Dimensional Echocardiography and Computational Fluid Dynamics |
| title_short | An Interactive Computational Pipeline to Investigate Ventricular Hemodynamics with Real‐Time Three‐Dimensional Echocardiography and Computational Fluid Dynamics |
| title_sort | interactive computational pipeline to investigate ventricular hemodynamics with real time three dimensional echocardiography and computational fluid dynamics |
| topic | geometry processing moving mesh simulations real‐time three‐dimensional echocardiography ventricular hemodynamics |
| url | https://doi.org/10.1002/eng2.13041 |
| work_keys_str_mv | AT janniklasthiel aninteractivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT danielverhulsdonk aninteractivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT ulrichsteinseifer aninteractivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT katharinalinden aninteractivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT ulrikeherberg aninteractivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT ingeborgfriehs aninteractivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT danieldiazgil aninteractivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT michaelneidlin aninteractivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT janniklasthiel interactivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT danielverhulsdonk interactivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT ulrichsteinseifer interactivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT katharinalinden interactivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT ulrikeherberg interactivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT ingeborgfriehs interactivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT danieldiazgil interactivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics AT michaelneidlin interactivecomputationalpipelinetoinvestigateventricularhemodynamicswithrealtimethreedimensionalechocardiographyandcomputationalfluiddynamics |