Environmental enrichment attenuates social isolation-exacerbated postoperative cognitive dysfunction in aged mice via inhibition of RAGE-HMGB1 proinflammatory signaling
Microglial overactivation, leading to neuroinflammation, plays a pivotal role in the development of postoperative cognitive dysfunction (POCD). However, the reasons behind varying inflammatory and cognitive reactions to similar surgical stresses among individuals remain enigmatic. Social isolation (...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025002746 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|