Safety Profile, Toxicokinetic, and Intestinal Absorption Differences of a Naturally-Derived Anti-Rheumatic Drug, Sinomenine Hydrochloride, in Normal and Arthritic Rats

Safety Profile, Toxicokinetic, and Intestinal Absorption Differences of a Naturally-Derived Anti-Rheumatic Drug, Sinomenine Hydrochloride, in Normal and Arthritic Rats

<b>Background/Objective</b>: Sinomenine hydrochloride (SH), a natural anti–rheumatic drug derived from the Chinese medicinal plant <i>Sinomenium acutum</i>, demonstrates disease–modifying properties but lacks comprehensive safety and toxicokinetic (TK) comparisons between phy...

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Bibliographic Details
Main Authors: Yini He, Hong Huang, Gejing Li, Ye Zhang, Junjie He, Ye Lin, Feichi Wu, Jianye Yan, Xiong Cai, Liang Liu
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
sinomenine hydrochloride
adjuvant-induced arthritis
safety profile
toxicokinetic
intestinal absorption
P–glycoprotein
Online Access:https://www.mdpi.com/1999-4923/17/4/484
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