Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction
Abstract Aims The aim of this study was to elucidate the clinical characteristics, including frailty status, of patients with heart failure with preserved ejection fraction (HFpEF) in comparison with those in patients with heart failure with reduced ejection fraction (HFrEF) in a super‐aged region o...
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.13885 |
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| author | Tomoyuki Hamada Toru Kubo Kazuya Kawai Yoko Nakaoka Toshikazu Yabe Takashi Furuno Eisuke Yamada Hiroaki Kitaoka Kochi YOSACOI study |
| author_facet | Tomoyuki Hamada Toru Kubo Kazuya Kawai Yoko Nakaoka Toshikazu Yabe Takashi Furuno Eisuke Yamada Hiroaki Kitaoka Kochi YOSACOI study |
| author_sort | Tomoyuki Hamada |
| collection | DOAJ |
| description | Abstract Aims The aim of this study was to elucidate the clinical characteristics, including frailty status, of patients with heart failure with preserved ejection fraction (HFpEF) in comparison with those in patients with heart failure with reduced ejection fraction (HFrEF) in a super‐aged region of Japan. Methods and results Of the 1061 Japanese patients enrolled in the Kochi YOSACOI study, a multicentre registry, we divided 645 patients (median age of 81 years [interquartile range, 72–87 years]; women, 49.1%) into two groups, HFpEF patients (61.2%) and HFrEF patients (38.8%). Physical frailty was diagnosed on the basis of the Japanese version of Cardiovascular Health (J‐CHS) Study criteria. Patients for whom left ventricular ejection fraction data were not available (n = 19), patients with heart failure with mildly reduced ejection fraction (n = 172), and patients who were not assessed by the J‐CHS criteria (n = 225) were excluded. The median ages of the HFpEF and HFrEF patients were 84 and 76 years, respectively. The proportion of patients with HFpEF gradually increased with advance of age. The proportion of patients with three or more comorbidities was larger in HFpEF patients than in HFrEF patients (77.9% vs. 65.6%, P = 0.003). Handgrip strength was significantly lower in HFpEF patients than in HFrEF patients for both men (P < 0.001) and women (P = 0.041). Comfortable 5 m walking speed was significantly slower in HFpEF patients than in HFrEF patients (P < 0.001). The proportions of patients with physical frailty were 55.2% in HFpEF patients and 46.8% in HFrEF patients, and the proportion was significantly higher in HFpEF patients (P = 0.043). In multivariate analysis, physical frailty was associated with advanced age [odds ratio (OR), 1.030; 95% confidence interval (CI), 1.010–1.050; P = 0.023] and low albumin level (OR, 0.334; 95% CI, 0.192–0.582; P < 0.001) in HFpEF patients, and physical frailty was associated with women (OR, 2.150; 95% CI, 1.030–4.500; P = 0.042) and anaemia (OR, 2.840; 95% CI, 1.300–6.230; P = 0.003) in HFrEF patients. Conclusions In a super‐aged population of HF patients in Japan, HFpEF patients are more likely to be frail/have a high frailty status compared with HFrEF patients. The results suggested that physical frailty is associated with extracardiac factors in both HFpEF patients and HFrEF patients. |
| format | Article |
| id | doaj-art-cd30c1e3b4ec42b3b40a0dd3c1facb7a |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-cd30c1e3b4ec42b3b40a0dd3c1facb7a2025-02-05T05:22:10ZengWileyESC Heart Failure2055-58222022-06-01931853186310.1002/ehf2.13885Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fractionTomoyuki Hamada0Toru Kubo1Kazuya Kawai2Yoko Nakaoka3Toshikazu Yabe4Takashi Furuno5Eisuke Yamada6Hiroaki Kitaoka7Kochi YOSACOI studyDepartment of Cardiology and Geriatrics, Kochi Medical School Kochi University Kochi 783‐8505 JapanDepartment of Cardiology and Geriatrics, Kochi Medical School Kochi University Kochi 783‐8505 JapanDepartment of Cardiology Chikamori Hospital Kochi JapanDepartment of Cardiology Chikamori Hospital Kochi JapanDepartment of Cardiology Kochi Prefectural Hatakenmin Hospital Sukumo JapanDepartment of Cardiology Kochi Prefectural Aki General Hospital Aki JapanDepartment of Cardiology Susaki Kuroshio Hospital Susaki JapanDepartment of Cardiology and Geriatrics, Kochi Medical School Kochi University Kochi 783‐8505 JapanAbstract Aims The aim of this study was to elucidate the clinical characteristics, including frailty status, of patients with heart failure with preserved ejection fraction (HFpEF) in comparison with those in patients with heart failure with reduced ejection fraction (HFrEF) in a super‐aged region of Japan. Methods and results Of the 1061 Japanese patients enrolled in the Kochi YOSACOI study, a multicentre registry, we divided 645 patients (median age of 81 years [interquartile range, 72–87 years]; women, 49.1%) into two groups, HFpEF patients (61.2%) and HFrEF patients (38.8%). Physical frailty was diagnosed on the basis of the Japanese version of Cardiovascular Health (J‐CHS) Study criteria. Patients for whom left ventricular ejection fraction data were not available (n = 19), patients with heart failure with mildly reduced ejection fraction (n = 172), and patients who were not assessed by the J‐CHS criteria (n = 225) were excluded. The median ages of the HFpEF and HFrEF patients were 84 and 76 years, respectively. The proportion of patients with HFpEF gradually increased with advance of age. The proportion of patients with three or more comorbidities was larger in HFpEF patients than in HFrEF patients (77.9% vs. 65.6%, P = 0.003). Handgrip strength was significantly lower in HFpEF patients than in HFrEF patients for both men (P < 0.001) and women (P = 0.041). Comfortable 5 m walking speed was significantly slower in HFpEF patients than in HFrEF patients (P < 0.001). The proportions of patients with physical frailty were 55.2% in HFpEF patients and 46.8% in HFrEF patients, and the proportion was significantly higher in HFpEF patients (P = 0.043). In multivariate analysis, physical frailty was associated with advanced age [odds ratio (OR), 1.030; 95% confidence interval (CI), 1.010–1.050; P = 0.023] and low albumin level (OR, 0.334; 95% CI, 0.192–0.582; P < 0.001) in HFpEF patients, and physical frailty was associated with women (OR, 2.150; 95% CI, 1.030–4.500; P = 0.042) and anaemia (OR, 2.840; 95% CI, 1.300–6.230; P = 0.003) in HFrEF patients. Conclusions In a super‐aged population of HF patients in Japan, HFpEF patients are more likely to be frail/have a high frailty status compared with HFrEF patients. The results suggested that physical frailty is associated with extracardiac factors in both HFpEF patients and HFrEF patients.https://doi.org/10.1002/ehf2.13885FrailtyPhysical functionHeart failureHeat failure with preserved ejection fractionElderly |
| spellingShingle | Tomoyuki Hamada Toru Kubo Kazuya Kawai Yoko Nakaoka Toshikazu Yabe Takashi Furuno Eisuke Yamada Hiroaki Kitaoka Kochi YOSACOI study Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction ESC Heart Failure Frailty Physical function Heart failure Heat failure with preserved ejection fraction Elderly |
| title | Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction |
| title_full | Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction |
| title_fullStr | Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction |
| title_full_unstemmed | Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction |
| title_short | Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction |
| title_sort | clinical characteristics and frailty status in heart failure with preserved vs reduced ejection fraction |
| topic | Frailty Physical function Heart failure Heat failure with preserved ejection fraction Elderly |
| url | https://doi.org/10.1002/ehf2.13885 |
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