Regulatory Immunotherapy in Bone Marrow Transplantation
Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populati...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2011/768948 |
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| _version_ | 1832555494274760704 |
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| author | Vanessa Morales-Tirado Wioleta Luszczek Marié van der Merwe Asha Pillai |
| author_facet | Vanessa Morales-Tirado Wioleta Luszczek Marié van der Merwe Asha Pillai |
| author_sort | Vanessa Morales-Tirado |
| collection | DOAJ |
| description | Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT. |
| format | Article |
| id | doaj-art-ccf6f8acc2f54840aa67ba8d7773cbf9 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ccf6f8acc2f54840aa67ba8d7773cbf92025-02-03T05:48:03ZengWileyThe Scientific World Journal1537-744X2011-01-01112620263410.1100/2011/768948768948Regulatory Immunotherapy in Bone Marrow TransplantationVanessa Morales-Tirado0Wioleta Luszczek1Marié van der Merwe2Asha Pillai3Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USADepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USADepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USADepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USAEvery year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.http://dx.doi.org/10.1100/2011/768948 |
| spellingShingle | Vanessa Morales-Tirado Wioleta Luszczek Marié van der Merwe Asha Pillai Regulatory Immunotherapy in Bone Marrow Transplantation The Scientific World Journal |
| title | Regulatory Immunotherapy in Bone Marrow Transplantation |
| title_full | Regulatory Immunotherapy in Bone Marrow Transplantation |
| title_fullStr | Regulatory Immunotherapy in Bone Marrow Transplantation |
| title_full_unstemmed | Regulatory Immunotherapy in Bone Marrow Transplantation |
| title_short | Regulatory Immunotherapy in Bone Marrow Transplantation |
| title_sort | regulatory immunotherapy in bone marrow transplantation |
| url | http://dx.doi.org/10.1100/2011/768948 |
| work_keys_str_mv | AT vanessamoralestirado regulatoryimmunotherapyinbonemarrowtransplantation AT wioletaluszczek regulatoryimmunotherapyinbonemarrowtransplantation AT marievandermerwe regulatoryimmunotherapyinbonemarrowtransplantation AT ashapillai regulatoryimmunotherapyinbonemarrowtransplantation |