Terpinen-4-ol Targets HIF-1α/TGF-β1/TNF-α Axis to Attenuate Ethanol-Induced Hepatotoxicity: Network Pharmacology and In Vitro Validation

Terpinen-4-ol Targets HIF-1α/TGF-β1/TNF-α Axis to Attenuate Ethanol-Induced Hepatotoxicity: Network Pharmacology and In Vitro Validation

<i>Background and Objective:</i> Alcoholic liver disease (ALD) is a major health burden caused by chronic alcohol consumption, leading to oxidative stress, inflammation, and fibrosis. Current treatments are limited, highlighting the need for novel therapeutic agents. This study investiga...

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Bibliographic Details
Main Authors: Tariq G. Alsahli, Maryam Khalid, Muhammad Nasir Hayat Malik, Saud O. Alshammari
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Medicina
Subjects:
terpinen-4-ol
HepG2
network pharmacology
HIF-1α
TGF-β1
COL1A1
Online Access:https://www.mdpi.com/1648-9144/61/6/1048
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