Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances
Per- and poly-fluoroalkyl substances (PFAS) are highly persistent chemicals commonly found in surface protectants, and class B aqueous film forming foams (AFFF), and many other consumer and industrial products. As a result of their widespread application and use, PFAS are now found in environmental...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324014751 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591060486848512 |
|---|---|
| author | Kenneth N. Kikanme Adcharee Karnjanapiboonwong Rameshkumar Angappan Nicole M. Dennis Farzana Hossain Jamie G. Suski Christopher J. Salice Todd A. Anderson |
| author_facet | Kenneth N. Kikanme Adcharee Karnjanapiboonwong Rameshkumar Angappan Nicole M. Dennis Farzana Hossain Jamie G. Suski Christopher J. Salice Todd A. Anderson |
| author_sort | Kenneth N. Kikanme |
| collection | DOAJ |
| description | Per- and poly-fluoroalkyl substances (PFAS) are highly persistent chemicals commonly found in surface protectants, and class B aqueous film forming foams (AFFF), and many other consumer and industrial products. As a result of their widespread application and use, PFAS are now found in environmental media across the globe. Research has revealed that exposure to environmentally relevant concentrations of PFAS can reduce reproductive success and have immunological effects in laboratory animals, including birds. Further, PFAS can be passed down from parents to offspring, posing a threat to sensitive life stages. PFAS may enter the brain by disrupting tight junctions or binding to transporters, but our overall understanding of the interactions and accumulation of PFAS in the avian brain is limited due to the lack of data. We obtained archived samples of male-female pairs of Northern bobwhite quail (NBWQ) from chronic toxicity studies where adults were exposed to either individual PFAS or binary mixtures through drinking water for at least 60 days. PFAS were detected in the brains of exposed adult quail, while brains from control birds had only occasional detections of PFAS; mostly perfluorooctane sulfonic acid (PFOS), likely because our source of birds was pen-raised animals and many PFAS are ubiquitous. Despite similar average daily intake (ADI) for both males and females, we observed higher concentrations of most PFAS in the brains of male birds compared to female birds, with the exception of perfluoroheptanoic acid (PFHpA). For the binary mixture exposures, PFOS appeared to reduce brain concentrations of perfluorohexane sulfonic acid (PFHxS) in both males and females to levels that could not be explained by ADI differences alone. Collectively, study results demonstrated that brain accumulation of short-chain PFAS in birds was not significantly affected by sex, however, long-chain PFAS exposure resulted in avian brain accumulation with generally higher PFAS concentrations in males compared to females. The findings of this study offer insights into the accumulation of PFAS in the avian brain and suggest that there may be sex differences in potential risks associated with exposure to these pervasive chemicals. |
| format | Article |
| id | doaj-art-ccaad246883c4b849f21f9d97421e17f |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-ccaad246883c4b849f21f9d97421e17f2025-01-23T05:25:26ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117399Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substancesKenneth N. Kikanme0Adcharee Karnjanapiboonwong1Rameshkumar Angappan2Nicole M. Dennis3Farzana Hossain4Jamie G. Suski5Christopher J. Salice6Todd A. Anderson7Department of Environmental Toxicology, Texas Tech University, Lubbock, TX, United States; Corresponding author.Department of Environmental Toxicology, Texas Tech University, Lubbock, TX, United StatesDepartment of Environmental Toxicology, Texas Tech University, Lubbock, TX, United StatesDepartment of Environmental and Global Health, University of Florida, Gainesville, FL, United StatesDepartment of Environmental Toxicology, Texas Tech University, Lubbock, TX, United StatesEA Engineering, Science, and Technology, Inc., PBC, Hunt Valley, MD, United StatesEnvironmental Science and Studies, Towson University, Towson, MD, United StatesDepartment of Environmental Toxicology, Texas Tech University, Lubbock, TX, United StatesPer- and poly-fluoroalkyl substances (PFAS) are highly persistent chemicals commonly found in surface protectants, and class B aqueous film forming foams (AFFF), and many other consumer and industrial products. As a result of their widespread application and use, PFAS are now found in environmental media across the globe. Research has revealed that exposure to environmentally relevant concentrations of PFAS can reduce reproductive success and have immunological effects in laboratory animals, including birds. Further, PFAS can be passed down from parents to offspring, posing a threat to sensitive life stages. PFAS may enter the brain by disrupting tight junctions or binding to transporters, but our overall understanding of the interactions and accumulation of PFAS in the avian brain is limited due to the lack of data. We obtained archived samples of male-female pairs of Northern bobwhite quail (NBWQ) from chronic toxicity studies where adults were exposed to either individual PFAS or binary mixtures through drinking water for at least 60 days. PFAS were detected in the brains of exposed adult quail, while brains from control birds had only occasional detections of PFAS; mostly perfluorooctane sulfonic acid (PFOS), likely because our source of birds was pen-raised animals and many PFAS are ubiquitous. Despite similar average daily intake (ADI) for both males and females, we observed higher concentrations of most PFAS in the brains of male birds compared to female birds, with the exception of perfluoroheptanoic acid (PFHpA). For the binary mixture exposures, PFOS appeared to reduce brain concentrations of perfluorohexane sulfonic acid (PFHxS) in both males and females to levels that could not be explained by ADI differences alone. Collectively, study results demonstrated that brain accumulation of short-chain PFAS in birds was not significantly affected by sex, however, long-chain PFAS exposure resulted in avian brain accumulation with generally higher PFAS concentrations in males compared to females. The findings of this study offer insights into the accumulation of PFAS in the avian brain and suggest that there may be sex differences in potential risks associated with exposure to these pervasive chemicals.http://www.sciencedirect.com/science/article/pii/S0147651324014751PFASBrainBioaccumulationMaternal transferSex difference |
| spellingShingle | Kenneth N. Kikanme Adcharee Karnjanapiboonwong Rameshkumar Angappan Nicole M. Dennis Farzana Hossain Jamie G. Suski Christopher J. Salice Todd A. Anderson Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances Ecotoxicology and Environmental Safety PFAS Brain Bioaccumulation Maternal transfer Sex difference |
| title | Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances |
| title_full | Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances |
| title_fullStr | Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances |
| title_full_unstemmed | Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances |
| title_short | Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances |
| title_sort | maternal transfer and sex differences in brain bioaccumulation for northern bobwhite quail colinus virginianus exposed to per and poly fluoroalkyl substances |
| topic | PFAS Brain Bioaccumulation Maternal transfer Sex difference |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324014751 |
| work_keys_str_mv | AT kennethnkikanme maternaltransferandsexdifferencesinbrainbioaccumulationfornorthernbobwhitequailcolinusvirginianusexposedtoperandpolyfluoroalkylsubstances AT adchareekarnjanapiboonwong maternaltransferandsexdifferencesinbrainbioaccumulationfornorthernbobwhitequailcolinusvirginianusexposedtoperandpolyfluoroalkylsubstances AT rameshkumarangappan maternaltransferandsexdifferencesinbrainbioaccumulationfornorthernbobwhitequailcolinusvirginianusexposedtoperandpolyfluoroalkylsubstances AT nicolemdennis maternaltransferandsexdifferencesinbrainbioaccumulationfornorthernbobwhitequailcolinusvirginianusexposedtoperandpolyfluoroalkylsubstances AT farzanahossain maternaltransferandsexdifferencesinbrainbioaccumulationfornorthernbobwhitequailcolinusvirginianusexposedtoperandpolyfluoroalkylsubstances AT jamiegsuski maternaltransferandsexdifferencesinbrainbioaccumulationfornorthernbobwhitequailcolinusvirginianusexposedtoperandpolyfluoroalkylsubstances AT christopherjsalice maternaltransferandsexdifferencesinbrainbioaccumulationfornorthernbobwhitequailcolinusvirginianusexposedtoperandpolyfluoroalkylsubstances AT toddaanderson maternaltransferandsexdifferencesinbrainbioaccumulationfornorthernbobwhitequailcolinusvirginianusexposedtoperandpolyfluoroalkylsubstances |