A radical hydrohaloalkylation of the ligand sphere of a chiral dehydroalanine Ni(II) complex: An asymmetric route to halogenated α-amino acid derivatives

A radical hydrohaloalkylation of the ligand sphere of a chiral dehydroalanine Ni(II) complex: An asymmetric route to halogenated α-amino acid derivatives

An asymmetric synthetic protocol for the access to chiral artificial halogenated α-amino acid (α-AA) derivatives was elaborated through the radical functionalization of a double bond in the ligand sphere of a robust chiral dehydroalanine Belokon's Ni(II) complex by hydrohaloalkylation reaction....

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Bibliographic Details
Main Authors: Nadezhda V. Stoletova, Alexander F. Smol'yakov, Andrey A. Tyutyunov, Victor I. Maleev, Vladimir A. Larionov
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Tetrahedron Chem
Subjects:
Amino acids
Asymmetric synthesis
Halocarbons
Radical addition
Post-modification
Chiral nickel(II) complex
Online Access:http://www.sciencedirect.com/science/article/pii/S2666951X24000573
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