Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis
Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis. Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and, in relatively low grade, mainly mediated by th...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8127281 |
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| _version_ | 1832546973336469504 |
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| author | Jingbin Zhou Zhihong Zhao Chen He Feng Gao Yu Guo Feng Qu Yujie Liu |
| author_facet | Jingbin Zhou Zhihong Zhao Chen He Feng Gao Yu Guo Feng Qu Yujie Liu |
| author_sort | Jingbin Zhou |
| collection | DOAJ |
| description | Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis. Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and, in relatively low grade, mainly mediated by the innate immune system, especially macrophages. However, due to its low abundance, there is a lack of systematic studies on macrophages in the OA condition. Here, we have used single-cell RNA sequencing analysis to gain insight into the heterogeneity and functional specialization of human knee macrophages. We also compared the gene expression profiles of macrophages in healthy people and OA patients and found the characteristic changes of special macrophages in the OA knee. We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies. |
| format | Article |
| id | doaj-art-cc7f4c0d57ef4e4e9390879db210dbd5 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-cc7f4c0d57ef4e4e9390879db210dbd52025-02-03T06:46:36ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/81272818127281Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human OsteoarthritisJingbin Zhou0Zhihong Zhao1Chen He2Feng Gao3Yu Guo4Feng Qu5Yujie Liu6Medical School of Chinese PLA, Beijing 100853, ChinaDepartment of Orthopedics, Beijing Second Hospital, Beijing 100031, ChinaChinese National Institute of Sports Medicine, Beijing 100061, ChinaChinese National Institute of Sports Medicine, Beijing 100061, ChinaDepartment of Orthopedics, Beijing Second Hospital, Beijing 100031, ChinaDepartment of Foot and Ankle Surgery, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100730, ChinaMedical School of Chinese PLA, Beijing 100853, ChinaOsteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis. Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and, in relatively low grade, mainly mediated by the innate immune system, especially macrophages. However, due to its low abundance, there is a lack of systematic studies on macrophages in the OA condition. Here, we have used single-cell RNA sequencing analysis to gain insight into the heterogeneity and functional specialization of human knee macrophages. We also compared the gene expression profiles of macrophages in healthy people and OA patients and found the characteristic changes of special macrophages in the OA knee. We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies.http://dx.doi.org/10.1155/2020/8127281 |
| spellingShingle | Jingbin Zhou Zhihong Zhao Chen He Feng Gao Yu Guo Feng Qu Yujie Liu Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis Journal of Immunology Research |
| title | Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis |
| title_full | Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis |
| title_fullStr | Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis |
| title_full_unstemmed | Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis |
| title_short | Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis |
| title_sort | single cell transcriptome analysis profile of meniscal tissue macrophages in human osteoarthritis |
| url | http://dx.doi.org/10.1155/2020/8127281 |
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