Colonic Interposition in a Woman with Attenuated Familial Adenomatous Polyposis: Does the Location of the Colon Affect Polyp Formation?
Attenuated familial adenomatous polyposis (AFAP) is a rare but well-established cause of colorectal carcinoma and multiple polyps. The present paper describes a case of a woman diagnosed with colorectal cancer at 34 years of age and subsequently found to have AFAP by genetic testing. During infancy,...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2008/780204 |
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| author | Melanie D Beaton Brian Taylor David Driman Peter Ainsworth Paul C Adams |
| author_facet | Melanie D Beaton Brian Taylor David Driman Peter Ainsworth Paul C Adams |
| author_sort | Melanie D Beaton |
| collection | DOAJ |
| description | Attenuated familial adenomatous polyposis (AFAP) is a rare but well-established cause of colorectal carcinoma and multiple polyps. The present paper describes a case of a woman diagnosed with colorectal cancer at 34 years of age and subsequently found to have AFAP by genetic testing. During infancy, the patient underwent surgical correction of esophageal atresia with colonic interposition. While she had developed adenomatous polyps in her native cecum, there was no evidence of polyps or cancer in the segment of large intestine interposed between her upper esophagus and stomach. Therefore, various environmental differences between the upper and lower gastrointestinal tract may play a role in the expression of AFAP phenotype. |
| format | Article |
| id | doaj-art-cc7161d61c40492693b47bda9bd723ef |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-cc7161d61c40492693b47bda9bd723ef2025-02-03T01:22:06ZengWileyCanadian Journal of Gastroenterology0835-79002008-01-0122763463610.1155/2008/780204Colonic Interposition in a Woman with Attenuated Familial Adenomatous Polyposis: Does the Location of the Colon Affect Polyp Formation?Melanie D Beaton0Brian Taylor1David Driman2Peter Ainsworth3Paul C Adams4Department of Medicine, Division of Gastroenterology, Molecular Diagnostics Laboratory, London Health Sciences Centre, University of Western Ontario, London, Ontario, CanadaDepartment of Surgery, Division of General Surgery, Molecular Diagnostics Laboratory, London Health Sciences Centre, University of Western Ontario, London, Ontario, CanadaDepartment of Pathology, Molecular Diagnostics Laboratory, London Health Sciences Centre, University of Western Ontario, London, Ontario, CanadaDepartment of Biochemistry, Molecular Diagnostics Laboratory, London Health Sciences Centre, University of Western Ontario, London, Ontario, CanadaDepartment of Medicine, Division of Gastroenterology, Molecular Diagnostics Laboratory, London Health Sciences Centre, University of Western Ontario, London, Ontario, CanadaAttenuated familial adenomatous polyposis (AFAP) is a rare but well-established cause of colorectal carcinoma and multiple polyps. The present paper describes a case of a woman diagnosed with colorectal cancer at 34 years of age and subsequently found to have AFAP by genetic testing. During infancy, the patient underwent surgical correction of esophageal atresia with colonic interposition. While she had developed adenomatous polyps in her native cecum, there was no evidence of polyps or cancer in the segment of large intestine interposed between her upper esophagus and stomach. Therefore, various environmental differences between the upper and lower gastrointestinal tract may play a role in the expression of AFAP phenotype.http://dx.doi.org/10.1155/2008/780204 |
| spellingShingle | Melanie D Beaton Brian Taylor David Driman Peter Ainsworth Paul C Adams Colonic Interposition in a Woman with Attenuated Familial Adenomatous Polyposis: Does the Location of the Colon Affect Polyp Formation? Canadian Journal of Gastroenterology |
| title | Colonic Interposition in a Woman with Attenuated Familial Adenomatous Polyposis: Does the Location of the Colon Affect Polyp Formation? |
| title_full | Colonic Interposition in a Woman with Attenuated Familial Adenomatous Polyposis: Does the Location of the Colon Affect Polyp Formation? |
| title_fullStr | Colonic Interposition in a Woman with Attenuated Familial Adenomatous Polyposis: Does the Location of the Colon Affect Polyp Formation? |
| title_full_unstemmed | Colonic Interposition in a Woman with Attenuated Familial Adenomatous Polyposis: Does the Location of the Colon Affect Polyp Formation? |
| title_short | Colonic Interposition in a Woman with Attenuated Familial Adenomatous Polyposis: Does the Location of the Colon Affect Polyp Formation? |
| title_sort | colonic interposition in a woman with attenuated familial adenomatous polyposis does the location of the colon affect polyp formation |
| url | http://dx.doi.org/10.1155/2008/780204 |
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