Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America
Background. The role of liver function tests (LFT) as prognostic factors in patients admitted with COVID-19 has not been fully investigated, particularly outside resource-rich countries. We aimed at evaluating the prognostic value of abnormal LFT on admission and during hospitalization of patients w...
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Wiley
2021-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2021/1622533 |
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| author | Domingo Balderramo Angelo Z. Mattos Victoria Mulqui Talita Chiesa Zuly Plácido-Damián Jaysoom Abarca Andrea Bolomo Yanina Carlino Isadora Z. Bombassaro Denusa Wiltgen Laura Tenorio Castillo Karina Díaz Johana Acuña Estela Manero Jhon Prieto Enrique Carrera Javier Díaz-Ferrer Jose D. Debes |
| author_facet | Domingo Balderramo Angelo Z. Mattos Victoria Mulqui Talita Chiesa Zuly Plácido-Damián Jaysoom Abarca Andrea Bolomo Yanina Carlino Isadora Z. Bombassaro Denusa Wiltgen Laura Tenorio Castillo Karina Díaz Johana Acuña Estela Manero Jhon Prieto Enrique Carrera Javier Díaz-Ferrer Jose D. Debes |
| author_sort | Domingo Balderramo |
| collection | DOAJ |
| description | Background. The role of liver function tests (LFT) as prognostic factors in patients admitted with COVID-19 has not been fully investigated, particularly outside resource-rich countries. We aimed at evaluating the prognostic value of abnormal LFT on admission and during hospitalization of patients with COVID-19. Methods. We performed a retrospective study that included 298 adult patients hospitalized for COVID-19, between 05/2020 and 02/2021, in 6 hospitals from 5 countries in South America. We analyzed demographic and comorbid variables and laboratory tests on admission and during hospitalization. LFT over twice the upper limit of normal (ALEx2) were also evaluated in relation to a variety of factors on admission and during hospitalization. De novo-ALEx2 was defined as the presence of ALEx2 at one week of hospitalization in patients without ALEx2 on admission. Patients were followed until hospital discharge or death. Multivariable analysis was used to evaluate the association between ALEx2 on admission and during hospitalization and mortality. Results. Of the total of 298 patients, 60% were male, with a mean age of 60 years, and 74% of patients had at least one comorbidity. Of those, 137 (46%) patients were transferred to the intensive care unit and 66 (22.1%) patients died during hospitalization. ALEx2 on admission was present in 87 (29.2%) patients and was found to be independently associated with 1-week mortality (odds ratio (OR) = 3.55; 95% confidence interval (95%CI) 1.05–12.05). Moreover, 84 (39.8%) out of 211 patients without ALEx2 at admission developed de novo-ALEx2, which was independently associated with mortality during second week of hospitalization (OR = 6.09; 95%CI 1.28–29) and overall mortality (OR = 2.93, 95%CI 1.05–8.19). Conclusions. A moderate elevation of LFT during admission was associated with a poor short-term prognosis in patients hospitalized with COVID-19. In addition, moderate elevation of LFT at one week of hospitalization was an independent risk factor for overall mortality in these patients. |
| format | Article |
| id | doaj-art-cc11120a92714c6c9905dabfec2429cf |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-cc11120a92714c6c9905dabfec2429cf2025-02-03T01:04:33ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972021-01-01202110.1155/2021/16225331622533Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South AmericaDomingo Balderramo0Angelo Z. Mattos1Victoria Mulqui2Talita Chiesa3Zuly Plácido-Damián4Jaysoom Abarca5Andrea Bolomo6Yanina Carlino7Isadora Z. Bombassaro8Denusa Wiltgen9Laura Tenorio Castillo10Karina Díaz11Johana Acuña12Estela Manero13Jhon Prieto14Enrique Carrera15Javier Díaz-Ferrer16Jose D. Debes17Gastroenterology Department, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, ArgentinaGraduate Program in Medicine: Hepatology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, BrazilGastroenterology Department, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, ArgentinaGastroenterology and Hepatology Unit, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, BrazilGastroenterology Department, Hospital Nacional Edgardo Rebagliati Martins-Essalud, School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PeruDepartment of Gastroenterology, Hospital Especialidades Eugenio Espejo, Universidad San Francisco de Quito, Quito, EcuadorGastroenterology Department, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, ArgentinaGastroenterology Department, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, ArgentinaGastroenterology and Hepatology Unit, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, BrazilGraduate Program in Medicine: Hepatology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, BrazilGastroenterology Department, Hospital Nacional Edgardo Rebagliati Martins-Essalud, School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PeruDepartment of Gastroenterology, Hospital Especialidades Eugenio Espejo, Universidad San Francisco de Quito, Quito, EcuadorDepartment of Gastroenterology, Hospital Especialidades Eugenio Espejo, Universidad San Francisco de Quito, Quito, EcuadorInternal Medicine Department, Hospital Pablo Soria, San Salvador de Jujuy, ArgentinaCentro de Enfermedades Hepaticas y Digestivas, Bogota, ColombiaDepartment of Gastroenterology, Hospital Especialidades Eugenio Espejo, Universidad San Francisco de Quito, Quito, EcuadorGastroenterology Department, Hospital Nacional Edgardo Rebagliati Martins-Essalud, School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PeruDepartment of Medicine, University of Minnesota, Minneapolis, USABackground. The role of liver function tests (LFT) as prognostic factors in patients admitted with COVID-19 has not been fully investigated, particularly outside resource-rich countries. We aimed at evaluating the prognostic value of abnormal LFT on admission and during hospitalization of patients with COVID-19. Methods. We performed a retrospective study that included 298 adult patients hospitalized for COVID-19, between 05/2020 and 02/2021, in 6 hospitals from 5 countries in South America. We analyzed demographic and comorbid variables and laboratory tests on admission and during hospitalization. LFT over twice the upper limit of normal (ALEx2) were also evaluated in relation to a variety of factors on admission and during hospitalization. De novo-ALEx2 was defined as the presence of ALEx2 at one week of hospitalization in patients without ALEx2 on admission. Patients were followed until hospital discharge or death. Multivariable analysis was used to evaluate the association between ALEx2 on admission and during hospitalization and mortality. Results. Of the total of 298 patients, 60% were male, with a mean age of 60 years, and 74% of patients had at least one comorbidity. Of those, 137 (46%) patients were transferred to the intensive care unit and 66 (22.1%) patients died during hospitalization. ALEx2 on admission was present in 87 (29.2%) patients and was found to be independently associated with 1-week mortality (odds ratio (OR) = 3.55; 95% confidence interval (95%CI) 1.05–12.05). Moreover, 84 (39.8%) out of 211 patients without ALEx2 at admission developed de novo-ALEx2, which was independently associated with mortality during second week of hospitalization (OR = 6.09; 95%CI 1.28–29) and overall mortality (OR = 2.93, 95%CI 1.05–8.19). Conclusions. A moderate elevation of LFT during admission was associated with a poor short-term prognosis in patients hospitalized with COVID-19. In addition, moderate elevation of LFT at one week of hospitalization was an independent risk factor for overall mortality in these patients.http://dx.doi.org/10.1155/2021/1622533 |
| spellingShingle | Domingo Balderramo Angelo Z. Mattos Victoria Mulqui Talita Chiesa Zuly Plácido-Damián Jaysoom Abarca Andrea Bolomo Yanina Carlino Isadora Z. Bombassaro Denusa Wiltgen Laura Tenorio Castillo Karina Díaz Johana Acuña Estela Manero Jhon Prieto Enrique Carrera Javier Díaz-Ferrer Jose D. Debes Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America Canadian Journal of Gastroenterology and Hepatology |
| title | Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America |
| title_full | Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America |
| title_fullStr | Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America |
| title_full_unstemmed | Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America |
| title_short | Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America |
| title_sort | abnormal liver tests during hospitalization predict mortality in patients with covid 19 a multicenter study from south america |
| url | http://dx.doi.org/10.1155/2021/1622533 |
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