Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular Amastigotes
Caffeic acid phenethyl ester (CAPE) is a polyphenol produced by many plants and is found in red and green propolis. Here, we evaluated the antileishmanial activity of this natural product against <i>Leishmania amazonensis</i>. CAPE exhibited IC<sub>50</sub> values of 8.07 µM...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/14/4/384 |
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| Summary: | Caffeic acid phenethyl ester (CAPE) is a polyphenol produced by many plants and is found in red and green propolis. Here, we evaluated the antileishmanial activity of this natural product against <i>Leishmania amazonensis</i>. CAPE exhibited IC<sub>50</sub> values of 8.07 µM (95% CI, 6.79–9.62 µM) and 13.51 µM (95% CI, 10.71–17.16 µM) against <i>L. amazonensis</i> promastigotes and intracellular amastigotes, respectively. Additionally, CAPE inhibited <i>L. amazonensis</i> arginase in a non-competitive manner with a K<sub>i</sub> value of 1.51 ± 0.04 µM. These results highlight the potential of CAPE as a promising lead compound for developing new therapies against leishmaniasis. |
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| ISSN: | 2076-0817 |