Primary intracranial malignant melanoma in an adolescent: case report and literature review
Primary intracranial malignant melanoma (PIMM) is an exceedingly rare central nervous system tumor, accounting for only 1% of melanoma cases and 0.07% of primary CNS tumors, with limited documentation in adolescents. This case report describes an 18-year-old male who presented with a seizure, markin...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2025.1524204/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860374413246464 |
|---|---|
| author | Nyoman Golden I Gusti Ketut Agung Surya Kencana Christopher Lauren Angky Saputra Denny Japardi |
| author_facet | Nyoman Golden I Gusti Ketut Agung Surya Kencana Christopher Lauren Angky Saputra Denny Japardi |
| author_sort | Nyoman Golden |
| collection | DOAJ |
| description | Primary intracranial malignant melanoma (PIMM) is an exceedingly rare central nervous system tumor, accounting for only 1% of melanoma cases and 0.07% of primary CNS tumors, with limited documentation in adolescents. This case report describes an 18-year-old male who presented with a seizure, marking the onset of his symptoms. Following an emergency assessment, MRI identified a heterogeneous mass in the right parasagittal frontal region, initially misdiagnosed as a cystic meningioma. A craniotomy allowed for total tumor resection, and histopathological analysis revealed a malignant melanoma characterized by neoplastic cells with pronounced nuclear pleomorphism and significant mitotic activity. Postoperative evaluations, including a PET scan, confirmed no extracranial melanoma, affirming the diagnosis of primary CNS melanoma. The patient demonstrated no neurological deficits or seizures one year post-surgery and was managed with adjuvant radiotherapy. This report emphasizes the necessity of considering PIMM in differential diagnoses for seizures in young patients and highlights the importance of comprehensive diagnostic evaluations, including MRI and histopathology, in rare cases. Additionally, the findings underscore the critical role of complete surgical resection in improving outcomes, with adjuvant therapies potentially enhancing long-term management and surveillance. As PIMM presents with nonspecific symptoms, awareness among clinicians is essential for early detection and appropriate intervention, warranting further research to develop standardized treatment protocols and enhance understanding of this rare tumor's pathophysiology. |
| format | Article |
| id | doaj-art-cbeb4e66f0ab4fe395d6ec5a62e77fcc |
| institution | Kabale University |
| issn | 2296-875X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj-art-cbeb4e66f0ab4fe395d6ec5a62e77fcc2025-02-10T15:06:01ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2025-02-011210.3389/fsurg.2025.15242041524204Primary intracranial malignant melanoma in an adolescent: case report and literature reviewNyoman GoldenI Gusti Ketut Agung Surya KencanaChristopher LaurenAngky SaputraDenny JapardiPrimary intracranial malignant melanoma (PIMM) is an exceedingly rare central nervous system tumor, accounting for only 1% of melanoma cases and 0.07% of primary CNS tumors, with limited documentation in adolescents. This case report describes an 18-year-old male who presented with a seizure, marking the onset of his symptoms. Following an emergency assessment, MRI identified a heterogeneous mass in the right parasagittal frontal region, initially misdiagnosed as a cystic meningioma. A craniotomy allowed for total tumor resection, and histopathological analysis revealed a malignant melanoma characterized by neoplastic cells with pronounced nuclear pleomorphism and significant mitotic activity. Postoperative evaluations, including a PET scan, confirmed no extracranial melanoma, affirming the diagnosis of primary CNS melanoma. The patient demonstrated no neurological deficits or seizures one year post-surgery and was managed with adjuvant radiotherapy. This report emphasizes the necessity of considering PIMM in differential diagnoses for seizures in young patients and highlights the importance of comprehensive diagnostic evaluations, including MRI and histopathology, in rare cases. Additionally, the findings underscore the critical role of complete surgical resection in improving outcomes, with adjuvant therapies potentially enhancing long-term management and surveillance. As PIMM presents with nonspecific symptoms, awareness among clinicians is essential for early detection and appropriate intervention, warranting further research to develop standardized treatment protocols and enhance understanding of this rare tumor's pathophysiology.https://www.frontiersin.org/articles/10.3389/fsurg.2025.1524204/fullmalignant melanomamalignant neoplasmneurosurgical proceduresoncologytumor |
| spellingShingle | Nyoman Golden I Gusti Ketut Agung Surya Kencana Christopher Lauren Angky Saputra Denny Japardi Primary intracranial malignant melanoma in an adolescent: case report and literature review Frontiers in Surgery malignant melanoma malignant neoplasm neurosurgical procedures oncology tumor |
| title | Primary intracranial malignant melanoma in an adolescent: case report and literature review |
| title_full | Primary intracranial malignant melanoma in an adolescent: case report and literature review |
| title_fullStr | Primary intracranial malignant melanoma in an adolescent: case report and literature review |
| title_full_unstemmed | Primary intracranial malignant melanoma in an adolescent: case report and literature review |
| title_short | Primary intracranial malignant melanoma in an adolescent: case report and literature review |
| title_sort | primary intracranial malignant melanoma in an adolescent case report and literature review |
| topic | malignant melanoma malignant neoplasm neurosurgical procedures oncology tumor |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2025.1524204/full |
| work_keys_str_mv | AT nyomangolden primaryintracranialmalignantmelanomainanadolescentcasereportandliteraturereview AT igustiketutagungsuryakencana primaryintracranialmalignantmelanomainanadolescentcasereportandliteraturereview AT christopherlauren primaryintracranialmalignantmelanomainanadolescentcasereportandliteraturereview AT angkysaputra primaryintracranialmalignantmelanomainanadolescentcasereportandliteraturereview AT dennyjapardi primaryintracranialmalignantmelanomainanadolescentcasereportandliteraturereview |