Case report: Multiple cryotherapy sessions in localized Darier's disease: a rare clinical presentation and literature review
Darier's disease (DD), a rare hereditary acantholytic dermatosis with high penetrance but variable expressivity, has about 10% of its cases presenting as localized lesions, known as Localized Darier's Disease (LDD). To date, only a very small number of non-segmental LDD cases have been rep...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1535961/full |
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| author | Yansi Lyu Bin Wang Lyuxin Guan Li Ma Hao Li |
| author_facet | Yansi Lyu Bin Wang Lyuxin Guan Li Ma Hao Li |
| author_sort | Yansi Lyu |
| collection | DOAJ |
| description | Darier's disease (DD), a rare hereditary acantholytic dermatosis with high penetrance but variable expressivity, has about 10% of its cases presenting as localized lesions, known as Localized Darier's Disease (LDD). To date, only a very small number of non-segmental LDD cases have been reported. This study reports a case of a 27-year-old Chinese male with LDD, who presented with yellow-brown papules and plaques on the inner side of the right thigh for 1 month. The diagnosis of localized keratosis follicularis was confirmed through dermatoscopic examination and histopathological assessment of the skin lesion. After repeated applications of cryotherapy combined with the use of emollients, while avoiding physical friction and sun exposure, the rash gradually subsided. The patient experienced no adverse reactions after treatment. The occurrence of LDD on the inner thigh, a relatively rare site, provides new insights into the affected areas of LDD, further expands the clinical manifestations of the disease, and offers valuable experience for clinicians in recognizing and managing LDD at different sites, aiding in the optimization of diagnostic and therapeutic strategies. |
| format | Article |
| id | doaj-art-cbdea7a89d1a4d819b6a4f6b38e9c221 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-cbdea7a89d1a4d819b6a4f6b38e9c2212025-01-30T05:10:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.15359611535961Case report: Multiple cryotherapy sessions in localized Darier's disease: a rare clinical presentation and literature reviewYansi Lyu0Bin Wang1Lyuxin Guan2Li Ma3Hao Li4Department of Dermatology, Shenzhen University General Hospital, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Shenzhen University General Hospital, Shenzhen, Guangdong, ChinaDepartment of Burn and Plastic Surgery, The First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaDepartment of Dermatology, Shenzhen University General Hospital, Shenzhen, Guangdong, ChinaThe University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, ChinaDarier's disease (DD), a rare hereditary acantholytic dermatosis with high penetrance but variable expressivity, has about 10% of its cases presenting as localized lesions, known as Localized Darier's Disease (LDD). To date, only a very small number of non-segmental LDD cases have been reported. This study reports a case of a 27-year-old Chinese male with LDD, who presented with yellow-brown papules and plaques on the inner side of the right thigh for 1 month. The diagnosis of localized keratosis follicularis was confirmed through dermatoscopic examination and histopathological assessment of the skin lesion. After repeated applications of cryotherapy combined with the use of emollients, while avoiding physical friction and sun exposure, the rash gradually subsided. The patient experienced no adverse reactions after treatment. The occurrence of LDD on the inner thigh, a relatively rare site, provides new insights into the affected areas of LDD, further expands the clinical manifestations of the disease, and offers valuable experience for clinicians in recognizing and managing LDD at different sites, aiding in the optimization of diagnostic and therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fmed.2025.1535961/fulllocalized Darier's diseasecryotherapythe inner thighclinical manifestationstherapeutic strategies |
| spellingShingle | Yansi Lyu Bin Wang Lyuxin Guan Li Ma Hao Li Case report: Multiple cryotherapy sessions in localized Darier's disease: a rare clinical presentation and literature review Frontiers in Medicine localized Darier's disease cryotherapy the inner thigh clinical manifestations therapeutic strategies |
| title | Case report: Multiple cryotherapy sessions in localized Darier's disease: a rare clinical presentation and literature review |
| title_full | Case report: Multiple cryotherapy sessions in localized Darier's disease: a rare clinical presentation and literature review |
| title_fullStr | Case report: Multiple cryotherapy sessions in localized Darier's disease: a rare clinical presentation and literature review |
| title_full_unstemmed | Case report: Multiple cryotherapy sessions in localized Darier's disease: a rare clinical presentation and literature review |
| title_short | Case report: Multiple cryotherapy sessions in localized Darier's disease: a rare clinical presentation and literature review |
| title_sort | case report multiple cryotherapy sessions in localized darier s disease a rare clinical presentation and literature review |
| topic | localized Darier's disease cryotherapy the inner thigh clinical manifestations therapeutic strategies |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1535961/full |
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