Protein phosphatase 1 regulatory subunit 15 A (PPP1R15A) promoted the progression of gastric cancer by activating cell autophagy under energy stress

Protein phosphatase 1 regulatory subunit 15 A (PPP1R15A) promoted the progression of gastric cancer by activating cell autophagy under energy stress

Abstract Background Glucose metabolism plays a critical role in tumor progression. When glucose intake is insufficient and the tumor’s growth rate exceeds its energy supply, tumor cells typically adapt and overcome the energy stress through compensatory mechanisms to maintain the survival of tumor c...

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Main Authors: Yingnan Cui, Xueyuan Cao, Yangyu Zhang, Chenhao Fu, Dongming Li, Yuanlin Sun, Yuzheng Zhang, Tingshuang Xu, Tetsuya Tsukamoto, Donghui Cao, Jing Jiang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gastric cancer
Energy stress
Autophagy
Protein Phosphatase 1 Regulatory Subunit 15A (PPP1R15A)
JUN
Online Access:https://doi.org/10.1186/s13046-025-03320-y
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https://doi.org/10.1186/s13046-025-03320-y

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