HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model.

HIV induces synaptic hyperexcitation via cGMP-dependent protein kinase II activation in the FIV infection model.

Over half of individuals infected with human immunodeficiency virus (HIV) suffer from HIV-associated neurocognitive disorders (HANDs), yet the molecular mechanisms leading to neuronal dysfunction are poorly understood. Feline immunodeficiency virus (FIV) naturally infects cats and shares its structu...

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Main Authors: Keira Sztukowski, Kaila Nip, Paige N Ostwald, Matheus F Sathler, Julianna L Sun, Jiayi Shou, Emily T Jorgensen, Travis E Brown, John H Elder, Craig Miller, Franz Hofmann, Sue VandeWoude, Seonil Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2005315
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https://doi.org/10.1371/journal.pbio.2005315

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