Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry
Clinical research indicates that negative calcium balance is associated with low bone mass, rapid bone loss, and high fracture rates. However, some studies revealed that not only calcium is involved in bone strengthening as risk factor of fracture osteoporosis. Thus, in this report, the difference o...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/372972 |
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| author | Zairin Noor Sutiman Bambang Sumitro Mohammad Hidayat Agus Hadian Rahim Akhmad Sabarudin Tomonari Umemura |
| author_facet | Zairin Noor Sutiman Bambang Sumitro Mohammad Hidayat Agus Hadian Rahim Akhmad Sabarudin Tomonari Umemura |
| author_sort | Zairin Noor |
| collection | DOAJ |
| description | Clinical research indicates that negative calcium balance is associated with low bone mass, rapid bone loss, and high fracture rates. However, some studies revealed that not only calcium is involved in bone strengthening as risk factor of fracture osteoporosis. Thus, in this report, the difference of metallic and nonmetallic elements in osteoporosis and normal bones was studied by high-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS). The influence of these elements on bone metabolic processes is also discussed. Inclusion criteria of bone samples consist of postmenopausal woman, trabecular bone fracture, normal and osteoporosis BMD value, and no history of previous disease. The results showed that the concentration of B, Al, S, V, Co, Mo, Te, Ba, La, Ni, As, and Ca/P ratio is higher in osteoporosis than normal. These atomic minerals have negative role to imbalance between bone resorption and bone formation activity. Conversely, concentrations of Na, Mg, P, K, Ca, Cr, Pd, Ag, Mn, Fe, Cu, Zn, Rb, Sr, Pb, and Se are lower in osteoporosis than in normal bones. Among these atoms, known to have important roles in bone structure, we found involvement of atomic mineral and calcium which are considerable to contribute to osteoporotic phenomena. |
| format | Article |
| id | doaj-art-cb20a5b2c9ed4af5b676ac7ea73d766b |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cb20a5b2c9ed4af5b676ac7ea73d766b2025-02-03T01:26:03ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/372972372972Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass SpectrometryZairin Noor0Sutiman Bambang Sumitro1Mohammad Hidayat2Agus Hadian Rahim3Akhmad Sabarudin4Tomonari Umemura5Department of Orthopaedics, Ulin General Hospital, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin 70232, IndonesiaDepartment of Biology, Faculty of Science, Brawijaya University, Malang 65145, IndonesiaDepartment of Orthopaedics, Syaiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang 65122, IndonesiaDepartment of Orthopaedics, Hasan Sadikin Hospital, Faculty of Medicine, Padjadjaran University, Bandung 40161, IndonesiaDepartment of Chemistry, Faculty of Science, Brawijaya University, Malang 65145, IndonesiaDivision of Nanomaterial Sciences, EcoTopia Science Institute, Nagoya University, Nagoya 464-8603, JapanClinical research indicates that negative calcium balance is associated with low bone mass, rapid bone loss, and high fracture rates. However, some studies revealed that not only calcium is involved in bone strengthening as risk factor of fracture osteoporosis. Thus, in this report, the difference of metallic and nonmetallic elements in osteoporosis and normal bones was studied by high-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS). The influence of these elements on bone metabolic processes is also discussed. Inclusion criteria of bone samples consist of postmenopausal woman, trabecular bone fracture, normal and osteoporosis BMD value, and no history of previous disease. The results showed that the concentration of B, Al, S, V, Co, Mo, Te, Ba, La, Ni, As, and Ca/P ratio is higher in osteoporosis than normal. These atomic minerals have negative role to imbalance between bone resorption and bone formation activity. Conversely, concentrations of Na, Mg, P, K, Ca, Cr, Pd, Ag, Mn, Fe, Cu, Zn, Rb, Sr, Pb, and Se are lower in osteoporosis than in normal bones. Among these atoms, known to have important roles in bone structure, we found involvement of atomic mineral and calcium which are considerable to contribute to osteoporotic phenomena.http://dx.doi.org/10.1100/2012/372972 |
| spellingShingle | Zairin Noor Sutiman Bambang Sumitro Mohammad Hidayat Agus Hadian Rahim Akhmad Sabarudin Tomonari Umemura Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry The Scientific World Journal |
| title | Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry |
| title_full | Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry |
| title_fullStr | Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry |
| title_full_unstemmed | Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry |
| title_short | Atomic Mineral Characteristics of Indonesian Osteoporosis by High-Resolution Inductively Coupled Plasma Mass Spectrometry |
| title_sort | atomic mineral characteristics of indonesian osteoporosis by high resolution inductively coupled plasma mass spectrometry |
| url | http://dx.doi.org/10.1100/2012/372972 |
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