Pathogenesis of Focal Segmental Glomerulosclerosis and Minimal Change Disease: Insights from Glomerular Proteomics

Pathogenesis of Focal Segmental Glomerulosclerosis and Minimal Change Disease: Insights from Glomerular Proteomics

Podocyte injury is a hallmark of both focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD), ultimately reflected in foot process effacement and proteinuria. Triggers and pathogenic pathways leading to podocyte cytoskeleton rearrangements are, however, incompletely explained. He...

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Main Authors: Yuriy Maslyennikov, Ioana-Ecaterina Pralea, Andrada Alina Bărar, Crina Claudia Rusu, Diana Tania Moldovan, Alina Ramona Potra, Dacian Tirinescu, Maria Țicală, Alexandra Urs, Paula Zamfir, Emil Boțan, Ximena-Maria Mureșan, Simina Pîrv, Andreea Nuțu, Ioana Berindan-Neagoe, Cristina-Adela Iuga, Ina Maria Kacso
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Life
Subjects:
focal segmental glomerulosclerosis
minimal change disease
proteomics
tissue
glomeruli
Online Access:https://www.mdpi.com/2075-1729/15/4/527
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