Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components

Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components

Abstract Extracellular vesicles (EVs) play a critical role in the development of neural cells in the central nervous system (CNS). Human neural rosettes (hNRs) are radial cell structures that assemble from induced pluripotent stem cells (hiPSCs) and recapitulate some stages of neural tube morphogene...

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Main Authors: Malena Herrera Lopez, Matías Bertone Arolfo, Mónica Remedi, Laura Gastaldi, Carlos Wilson, Gonzalo G. Guendulain, Danilo Ceschin, Andrés Cardozo Gizzi, Alfredo Cáceres, Ana Lis Moyano
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
CNS
Neurodevelopment
Extracellular vesicles
Stem cells
Neurite outgrowth
SOX2
Online Access:https://doi.org/10.1038/s41598-025-86094-9
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https://doi.org/10.1038/s41598-025-86094-9

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