Development of a refined experimental mouse model of myasthenia gravis with anti-acetylcholine receptor antibodies

Development of a refined experimental mouse model of myasthenia gravis with anti-acetylcholine receptor antibodies

Myasthenia gravis (MG) is an autoimmune disorder primarily caused by autoantibodies that target the acetylcholine receptor (AChR) at the neuromuscular junction (NMJ). The classical experimental autoimmune myasthenia gravis (C-EAMG) mouse model has long been used by immunizing mice with acetylcholine...

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Bibliographic Details
Main Authors: Axel You, Léa S. Lippens, Odessa-Maud Fayet, Solène Maillard, Laureline Betemps, Antony Grondin, Jean-Thomas Vilquin, Nadine Dragin, Rozen Le Panse
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
myasthenia gravis
experimental model
refinement
adjuvant
poly(I:C)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521382/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521382/full

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