Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug
Momordica charantia is a species cultivated throughout the world and widely used in folk medicine, and its medicinal benefits are well documented, especially its pharmacological properties, including antimicrobial activities. Analytical methods have been used to aid in the characterization of compou...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/7528297 |
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| author | Deysiane Oliveira Brandão Geovani Pereira Guimarães Ravely Lucena Santos Fernando José de Lima Ramos Júnior Karla Monik Alves da Silva Fabio Santos de Souza Rui Oliveira Macêdo |
| author_facet | Deysiane Oliveira Brandão Geovani Pereira Guimarães Ravely Lucena Santos Fernando José de Lima Ramos Júnior Karla Monik Alves da Silva Fabio Santos de Souza Rui Oliveira Macêdo |
| author_sort | Deysiane Oliveira Brandão |
| collection | DOAJ |
| description | Momordica charantia is a species cultivated throughout the world and widely used in folk medicine, and its medicinal benefits are well documented, especially its pharmacological properties, including antimicrobial activities. Analytical methods have been used to aid in the characterization of compounds derived from plant drug extracts and their products. This paper developed a methodological model to evaluate the integrity of the vegetable drug M. charantia in different particle sizes, using different analytical methods. M. charantia was collected in the semiarid region of Paraíba, Brazil. The herbal medicine raw material derived from the leaves and fruits in different particle sizes was analyzed using thermoanalytical techniques as thermogravimetry (TG) and differential thermal analysis (DTA), pyrolysis coupled to gas chromatography/mass spectrometry (PYR-GC/MS), and nuclear magnetic resonance (1H NMR), in addition to the determination of antimicrobial activity. The different particle surface area among the samples was differentiated by the techniques. DTA and TG were used for assessing thermal and kinetic parameters and PYR-GC/MS was used for degradation products chromatographic identification through the pyrograms. The infusions obtained from the fruit and leaves of Momordica charantia presented antimicrobial activity. |
| format | Article |
| id | doaj-art-cadf8d1564c24359bb51f0fc7fdd6da5 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-cadf8d1564c24359bb51f0fc7fdd6da52025-02-03T06:00:21ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732016-01-01201610.1155/2016/75282977528297Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable DrugDeysiane Oliveira Brandão0Geovani Pereira Guimarães1Ravely Lucena Santos2Fernando José de Lima Ramos Júnior3Karla Monik Alves da Silva4Fabio Santos de Souza5Rui Oliveira Macêdo6Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, 50740-521 Recife, PE, BrazilDepartment of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, 50740-521 Recife, PE, BrazilDepartment of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, 50740-521 Recife, PE, BrazilDepartment of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, 50740-521 Recife, PE, BrazilDepartment of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, 50740-521 Recife, PE, BrazilDepartment of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, 50740-521 Recife, PE, BrazilDepartment of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, 50740-521 Recife, PE, BrazilMomordica charantia is a species cultivated throughout the world and widely used in folk medicine, and its medicinal benefits are well documented, especially its pharmacological properties, including antimicrobial activities. Analytical methods have been used to aid in the characterization of compounds derived from plant drug extracts and their products. This paper developed a methodological model to evaluate the integrity of the vegetable drug M. charantia in different particle sizes, using different analytical methods. M. charantia was collected in the semiarid region of Paraíba, Brazil. The herbal medicine raw material derived from the leaves and fruits in different particle sizes was analyzed using thermoanalytical techniques as thermogravimetry (TG) and differential thermal analysis (DTA), pyrolysis coupled to gas chromatography/mass spectrometry (PYR-GC/MS), and nuclear magnetic resonance (1H NMR), in addition to the determination of antimicrobial activity. The different particle surface area among the samples was differentiated by the techniques. DTA and TG were used for assessing thermal and kinetic parameters and PYR-GC/MS was used for degradation products chromatographic identification through the pyrograms. The infusions obtained from the fruit and leaves of Momordica charantia presented antimicrobial activity.http://dx.doi.org/10.1155/2016/7528297 |
| spellingShingle | Deysiane Oliveira Brandão Geovani Pereira Guimarães Ravely Lucena Santos Fernando José de Lima Ramos Júnior Karla Monik Alves da Silva Fabio Santos de Souza Rui Oliveira Macêdo Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug Journal of Analytical Methods in Chemistry |
| title | Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug |
| title_full | Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug |
| title_fullStr | Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug |
| title_full_unstemmed | Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug |
| title_short | Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug |
| title_sort | model analytical development for physical chemical and biological characterization of momordica charantia vegetable drug |
| url | http://dx.doi.org/10.1155/2016/7528297 |
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