A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages

A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages

Abstract Osteoarthritis (OA) affects the entire knee joint, yet cross-tissue molecular interplay remains poorly understood. To address this, we constructed the first single-cell RNA sequencing atlas of knee OA, profiling articular cartilage, meniscus, synovium, and subchondral bone. Our analysis rev...

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Bibliographic Details
Main Authors: Rajnikant Dilip Raut, Amit Kumar Chakraborty, Tuhina Neogi, Michael Albro, Brian Snyder, Thomas P. Schaer, Chao Zhang, Mark W. Grinstaff, Manish V. Bais
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08586-8
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https://doi.org/10.1038/s42003-025-08586-8

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