Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study

Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study

BackgroundRenal cell carcinoma (RCC) is characterized by a high degree of genomic but also functional intratumoral heterogeneity (ITH). Mutations in VHL, chromatin remodeling genes such as SETD2 and genes that regulate the PI3K/AKT/mTOR pathway have been identified as recurrent drivers despite genom...

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Bibliographic Details
Main Authors: Jakob Wieke, Christina Jurcic, Adam Kaczorowski, Sarah Böning, Martina Kirchner, Constantin Schwab, Viktoria Schütz, Markus Hohenfellner, Anette Duensing, Albrecht Stenzinger, Stefan Duensing
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
Subjects:
renal cell carcinoma
tumor heterogeneity
genotype
phenotype
VHL
mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1551077/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1551077/full

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