Selective neoadjuvant therapy of rectal cancer patients (SELREC): study protocol for a European randomised controlled, open, multicentre non-inferiority trial

Selective neoadjuvant therapy of rectal cancer patients (SELREC): study protocol for a European randomised controlled, open, multicentre non-inferiority trial

Introduction Neoadjuvant (chemo)radiotherapy (n(C)RT) followed by resection with total mesorectal excision (TME) constitutes the standard treatment for patients with locally advanced rectal cancer of the middle and lower third. However, n(C)RT has demonstrated no significant impact on overall surviv...

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Main Authors: Markus W Büchler, Lukas Baumann, Peter Schirmacher, Christoph W Michalski, Markus K Diener, Dirk Jäger, Pascal Probst, Mohammed Al-Saeedi, Martin Schneider, Alexis Ulrich, Constantin Schwab, Anja Sander, Christina Klose, Christoph Kahlert, Hans-Ulrich Kauczor, Jürgen Debus, Rosa Klotz, Solveig Tenckhoff, Cosima Engerer, Kristin Uzun-Lang, Caroline Wild, Bruno C Köhler
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/6/e092807.full
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https://bmjopen.bmj.com/content/15/6/e092807.full

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