Modulating the gut microbiota and inflammation is involved in the effect of diosgenin against diabetic nephropathy in rat

Modulating the gut microbiota and inflammation is involved in the effect of diosgenin against diabetic nephropathy in rat

BackgroundDiabetic nephropathy (DN) is a severe complication of diabetes, which has been increasingly associated with gut microbiota dysbiosis and inflammatory dysregulation.ObjectiveThis study investigates the dual therapeutic potential of diosgenin (DIO), a steroidal sapogenin, in modulating the g...

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Main Authors: Jiang Shanshan, Pan Shu, Hu Xiao, Kudelaidi Kuerban, Zhu Hao, Wang Yujie, Wang Rong, Shi Yuhuan, Yuan Yongfang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
diosgenin
anti-inflammatory
gut microbiota
diabetic nephropathy
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1555849/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1555849/full

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