Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1+ Puerto Ricans: 2006–2010
This is a continuation of our efforts to maintain a record of the evolution of HIV-1 infection in Puerto Rico by monitoring the expression levels of antiretroviral drug-resistance-associated mutations. Samples from 2,500 patients from 2006–2010 were analyzed using the TruGene HIV-1 genotyping kit an...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2012/934041 |
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| author | Lycely del C. Sepúlveda-Torres Alexandra De La Rosa Luz Cumba Nawal Boukli Eddy Ríos-Olivares Luis A. Cubano |
| author_facet | Lycely del C. Sepúlveda-Torres Alexandra De La Rosa Luz Cumba Nawal Boukli Eddy Ríos-Olivares Luis A. Cubano |
| author_sort | Lycely del C. Sepúlveda-Torres |
| collection | DOAJ |
| description | This is a continuation of our efforts to maintain a record of the evolution of HIV-1 infection in Puerto Rico by monitoring the expression levels of antiretroviral drug-resistance-associated mutations. Samples from 2,500 patients from 2006–2010 were analyzed using the TruGene HIV-1 genotyping kit and the OpenGene DNA sequencing system. Results show that 58.8% of males and 65.3% of females had HIV-1 with resistance to at least one medication. The average number of HIV mutations was 6.0 in males and 6.1 in females. Statistically significant differences between men and women were recorded in the levels of HIV-1 expressed mutations and antiretroviral drug resistance. The most prevalent antiretroviral medication resistance shifted from zalcitabine to nevirapine and efavirenz in the five-year period. M184V and L63P were the dominant mutations for the reverse transcriptase and the protease genes, respectively, but an increase in the incidence of minority mutations was observed. |
| format | Article |
| id | doaj-art-ca67acf89e8242a7960ab841be2ae9c6 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-ca67acf89e8242a7960ab841be2ae9c62025-02-03T05:54:30ZengWileyAIDS Research and Treatment2090-12402090-12592012-01-01201210.1155/2012/934041934041Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1+ Puerto Ricans: 2006–2010Lycely del C. Sepúlveda-Torres0Alexandra De La Rosa1Luz Cumba2Nawal Boukli3Eddy Ríos-Olivares4Luis A. Cubano5Department of Microbiology and Immunology, Universidad Central del Caribe, P.O. Box 60327, Bayamón, PR 00960-6032, USADepartment of Microbiology and Immunology, Universidad Central del Caribe, P.O. Box 60327, Bayamón, PR 00960-6032, USASchool of Science and Technology, Universidad Metropolitana, P.O. Box 21150, San Juan, PR 00928-1150, USADepartment of Microbiology and Immunology, Universidad Central del Caribe, P.O. Box 60327, Bayamón, PR 00960-6032, USADepartment of Microbiology and Immunology, Universidad Central del Caribe, P.O. Box 60327, Bayamón, PR 00960-6032, USADepartment of Microbiology and Immunology, Universidad Central del Caribe, P.O. Box 60327, Bayamón, PR 00960-6032, USAThis is a continuation of our efforts to maintain a record of the evolution of HIV-1 infection in Puerto Rico by monitoring the expression levels of antiretroviral drug-resistance-associated mutations. Samples from 2,500 patients from 2006–2010 were analyzed using the TruGene HIV-1 genotyping kit and the OpenGene DNA sequencing system. Results show that 58.8% of males and 65.3% of females had HIV-1 with resistance to at least one medication. The average number of HIV mutations was 6.0 in males and 6.1 in females. Statistically significant differences between men and women were recorded in the levels of HIV-1 expressed mutations and antiretroviral drug resistance. The most prevalent antiretroviral medication resistance shifted from zalcitabine to nevirapine and efavirenz in the five-year period. M184V and L63P were the dominant mutations for the reverse transcriptase and the protease genes, respectively, but an increase in the incidence of minority mutations was observed.http://dx.doi.org/10.1155/2012/934041 |
| spellingShingle | Lycely del C. Sepúlveda-Torres Alexandra De La Rosa Luz Cumba Nawal Boukli Eddy Ríos-Olivares Luis A. Cubano Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1+ Puerto Ricans: 2006–2010 AIDS Research and Treatment |
| title | Prevalence of Drug Resistance and Associated Mutations
in a Population of HIV-1+ Puerto Ricans: 2006–2010 |
| title_full | Prevalence of Drug Resistance and Associated Mutations
in a Population of HIV-1+ Puerto Ricans: 2006–2010 |
| title_fullStr | Prevalence of Drug Resistance and Associated Mutations
in a Population of HIV-1+ Puerto Ricans: 2006–2010 |
| title_full_unstemmed | Prevalence of Drug Resistance and Associated Mutations
in a Population of HIV-1+ Puerto Ricans: 2006–2010 |
| title_short | Prevalence of Drug Resistance and Associated Mutations
in a Population of HIV-1+ Puerto Ricans: 2006–2010 |
| title_sort | prevalence of drug resistance and associated mutations in a population of hiv 1 puerto ricans 2006 2010 |
| url | http://dx.doi.org/10.1155/2012/934041 |
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