Microbial dysbiosis with tryptophan metabolites alteration in lower respiratory tract is associated with clinical responses to anti-PD-1 immunotherapy in advanced non-small cell lung cancer

Microbial dysbiosis with tryptophan metabolites alteration in lower respiratory tract is associated with clinical responses to anti-PD-1 immunotherapy in advanced non-small cell lung cancer

Abstract Lower respiratory tract microbiome constitutes a unique immune microenvironment for advanced non-small cell lung cancer as one of dominant localized microbial components. However, there exists little knowledge on the associations between this regional microbiome and clinical responses to an...

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Main Authors: Xiang-xiang Chen, Qing Ju, Dan Qiu, Ying Zhou, Yuan Wang, Xin-xin Zhang, Jing-geng Li, Min Wang, Ning Chang, Xiang-rui Xu, Yi-bo Zhang, Tong Zhao, Ke Wang, Yong Zhang, Jian Zhang
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Advanced non-small cell lung cancer
Lower respiratory tract microbiome
Tryptophan metabolites
Anti-PD-1 immunotherapy
Clinical responses
Online Access:https://doi.org/10.1007/s00262-025-03996-3
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https://doi.org/10.1007/s00262-025-03996-3

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