Improving Cofactor Promiscuity of HMG-CoA Reductase from <i>Ruegeria pomeroyi</i> Through Rational Design

Improving Cofactor Promiscuity of HMG-CoA Reductase from <i>Ruegeria pomeroyi</i> Through Rational Design

The mevalonate pathway is crucial for synthesizing isopentenyl pyrophosphate (IPP), the universal precursor of terpenoids, with 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) serving as the rate-determining enzyme that catalyzes the reduction of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonat...

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Bibliographic Details
Main Authors: Haizhao Xue, Yanzhe Huang, Aabid Manzoor Shah, Xueying Wang, Yinghan Hu, Lingyun Zhang, Zongbao K. Zhao
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomolecules
Subjects:
mevalonate pathway
3-hydroxy-3-methylglutaryl-coenzyme A reductase
rational design
dual-cofactor specificity
Online Access:https://www.mdpi.com/2218-273X/15/7/976
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