Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer

Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer

Abstract Background Although the TNM staging system plays a critical role in guiding adjuvant chemotherapy for colorectal cancer (CRC), its precision for risk stratification in stage II and III CRC patients with proficient DNA mismatch repair (pMMR) remains limited. Therefore, precise predictive mod...

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Main Authors: Tong Wu, Lin Fang, Yuli Ruan, Mengde Shi, Dan Su, Yue Ma, Ming Ma, Bojun Wang, Yuanyu Liao, Shuling Han, Xiaolin Lu, Chunhui Zhang, Chao Liu, Yanqiao Zhang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Regulatory-immunoscore
Tertiary lymphoid structures
Tumor budding
Tumor aggression-defense index
Online Access:https://doi.org/10.1186/s12967-025-06141-x
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https://doi.org/10.1186/s12967-025-06141-x

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