Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration

Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration

Abstract Nucleus pulposus cells (NPCs) undergo metabolic disorders and matrix pathological remodeling under the influence of various adverse factors during intervertebral disc degeneration (IVDD), whereas post-translational modifications (PTMs) can confer cells with the capacity to respond quickly a...

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Main Authors: Xiaoyu Zhang, Qianping Guo, Jiawei Fang, Qi Cheng, Zhuang Zhu, Qifan Yu, Huan Wang, Youzhi Hong, Chengyuan Liu, Huilin Yang, Caihong Zhu, Bin Li, Li Ni
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Sequentially assembled nanoplatform
Co-delivery
Post-translational modifications
Mitochondrial homeostasis
Intervertebral disc degeneration
Online Access:https://doi.org/10.1186/s12951-025-03401-2
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https://doi.org/10.1186/s12951-025-03401-2

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