Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease
Activation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). In the innate immune system, Toll-like receptors (TLRs) are sensors that recognize bacterial and viral components such as lipopolysaccharide, bacterial DNA, and pep...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/362847 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562218084859904 |
|---|---|
| author | Kouichi Miura Ekihiro Seki Hirohide Ohnishi David A. Brenner |
| author_facet | Kouichi Miura Ekihiro Seki Hirohide Ohnishi David A. Brenner |
| author_sort | Kouichi Miura |
| collection | DOAJ |
| description | Activation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). In the innate immune system, Toll-like receptors (TLRs) are sensors that recognize bacterial and viral components such as lipopolysaccharide, bacterial DNA, and peptidoglycan. Recent data have demonstrated that the liver is exposed to a high load of TLR ligands due to bacterial overgrowth and increased intestinal permeability in NAFLD. Upon stimulation by these TLR ligands, hepatic immune cells produce various mediators that are involved in host defense. On the other hand, these mediators alter lipid metabolism, insulin signaling, and cell survival. Indeed, some TLR-deficient mice demonstrate lesser degrees of NAFLD even though TLR ligands are increased. This paper will highlight the recent progress on the study of TLR signaling and their downstream molecules in the development of NAFLD. |
| format | Article |
| id | doaj-art-ca230516fa73447d84f79428c673169d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ca230516fa73447d84f79428c673169d2025-02-03T01:23:16ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/362847362847Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver DiseaseKouichi Miura0Ekihiro Seki1Hirohide Ohnishi2David A. Brenner3Department of Gastroenterology and Neurology, Akita University Graduate School of Medicine, 1-1-1 Hondo Akita-shi, Akita 010-8543, JapanDepartment of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USADepartment of Gastroenterology and Neurology, Akita University Graduate School of Medicine, 1-1-1 Hondo Akita-shi, Akita 010-8543, JapanDepartment of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USAActivation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). In the innate immune system, Toll-like receptors (TLRs) are sensors that recognize bacterial and viral components such as lipopolysaccharide, bacterial DNA, and peptidoglycan. Recent data have demonstrated that the liver is exposed to a high load of TLR ligands due to bacterial overgrowth and increased intestinal permeability in NAFLD. Upon stimulation by these TLR ligands, hepatic immune cells produce various mediators that are involved in host defense. On the other hand, these mediators alter lipid metabolism, insulin signaling, and cell survival. Indeed, some TLR-deficient mice demonstrate lesser degrees of NAFLD even though TLR ligands are increased. This paper will highlight the recent progress on the study of TLR signaling and their downstream molecules in the development of NAFLD.http://dx.doi.org/10.1155/2010/362847 |
| spellingShingle | Kouichi Miura Ekihiro Seki Hirohide Ohnishi David A. Brenner Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease Gastroenterology Research and Practice |
| title | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease |
| title_full | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease |
| title_fullStr | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease |
| title_short | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease |
| title_sort | role of toll like receptors and their downstream molecules in the development of nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2010/362847 |
| work_keys_str_mv | AT kouichimiura roleoftolllikereceptorsandtheirdownstreammoleculesinthedevelopmentofnonalcoholicfattyliverdisease AT ekihiroseki roleoftolllikereceptorsandtheirdownstreammoleculesinthedevelopmentofnonalcoholicfattyliverdisease AT hirohideohnishi roleoftolllikereceptorsandtheirdownstreammoleculesinthedevelopmentofnonalcoholicfattyliverdisease AT davidabrenner roleoftolllikereceptorsandtheirdownstreammoleculesinthedevelopmentofnonalcoholicfattyliverdisease |