Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction

Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction

Introduction: Despite the high morbidity and mortality, the effective therapies for heart failure with preserved fraction (HFpEF) are limited as the poor understand of its pathophysiological basis. Objective: This study was aimed to characterize the cellular heterogeneity and potential mechanisms of...

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Bibliographic Details
Main Authors: Guoxing Li, Huilin Zhao, Zhe Cheng, Junjin Liu, Gang Li, Yongzheng Guo
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Advanced Research
Subjects:
HFpEF
scRNA-seq
ANGPTL4
Metabolism
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224000687
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