The KDM5A/HOXA5 axis regulates osteosarcoma progression via activating the Wnt/β-catenin pathway

The KDM5A/HOXA5 axis regulates osteosarcoma progression via activating the Wnt/β-catenin pathway

Abstract As an oncogenic driver, lysine-specific demethylase 5A (KDM5A) participates in regulating numerous tumor progression-related processes. Moreover, KDM5A functions as a histone demethylase, modulating the expression levels of its target genes by adjusting methylation levels. However, the unde...

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Bibliographic Details
Main Authors: Yi Luo, Youzhi He, Yuxia Xu, Yongfu Wang, Li Yang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:European Journal of Medical Research
Subjects:
Lysine-specific demethylase 5A
Homeobox A5
Di- and tri-methylation of lysine 4 on histone H3
Methylation modification
Osteosarcoma
Online Access:https://doi.org/10.1186/s40001-025-02478-7
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https://doi.org/10.1186/s40001-025-02478-7

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