Lysyl oxidase inhibitors in colorectal cancer progression
The lysine oxidase (LOX) family, consisting of LOX and LOX-like-1–4 (LOXL1–LOXL4), catalyses the cross-linking reaction of collagen and elastin in the extracellular matrix (ECM). Numerous studies have demonstrated that LOX family members are dysregulated in a variety of cancers, including colorectal...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523324003590 |
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| author | Muxian Liu Jie Wang Meihong Liu |
| author_facet | Muxian Liu Jie Wang Meihong Liu |
| author_sort | Muxian Liu |
| collection | DOAJ |
| description | The lysine oxidase (LOX) family, consisting of LOX and LOX-like-1–4 (LOXL1–LOXL4), catalyses the cross-linking reaction of collagen and elastin in the extracellular matrix (ECM). Numerous studies have demonstrated that LOX family members are dysregulated in a variety of cancers, including colorectal cancer (CRC), and play a key role in cancer cell migration, proliferation, invasion and metastasis. Targeting LOX family proteins with specific inhibitors has therefore been developed as a new therapeutic strategy for cancer. In this paper, we review the role of LOX enzymes in the development and progression of CRC. In addition, we address recent advances in the development of LOX/LOXL inhibitors, highlighting the potential use of this inhibitor as an effective and complementary treatment for CRC. |
| format | Article |
| id | doaj-art-c9f93b9296da4c958335ea2967e755ae |
| institution | Kabale University |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-c9f93b9296da4c958335ea2967e755ae2025-01-22T05:41:24ZengElsevierTranslational Oncology1936-52332025-02-0152102233Lysyl oxidase inhibitors in colorectal cancer progressionMuxian Liu0Jie Wang1Meihong Liu2Department of Gastroenterology, Dongguan Tungwah Hospital, Dongguan City 523000, Guangdong, ChinaDepartment of Gastroenterology, Dongguan Tungwah Hospital, Dongguan City 523000, Guangdong, ChinaCorresponding author at: Department of Gastroenterology, Dongguan Tungwah Hospital, No.1 Dongcheng East Road, Dongguan City 523000, Guangdong Province, China.; Department of Gastroenterology, Dongguan Tungwah Hospital, Dongguan City 523000, Guangdong, ChinaThe lysine oxidase (LOX) family, consisting of LOX and LOX-like-1–4 (LOXL1–LOXL4), catalyses the cross-linking reaction of collagen and elastin in the extracellular matrix (ECM). Numerous studies have demonstrated that LOX family members are dysregulated in a variety of cancers, including colorectal cancer (CRC), and play a key role in cancer cell migration, proliferation, invasion and metastasis. Targeting LOX family proteins with specific inhibitors has therefore been developed as a new therapeutic strategy for cancer. In this paper, we review the role of LOX enzymes in the development and progression of CRC. In addition, we address recent advances in the development of LOX/LOXL inhibitors, highlighting the potential use of this inhibitor as an effective and complementary treatment for CRC.http://www.sciencedirect.com/science/article/pii/S1936523324003590Lysyl oxidaseColorectal cancerTherapeutic targets |
| spellingShingle | Muxian Liu Jie Wang Meihong Liu Lysyl oxidase inhibitors in colorectal cancer progression Translational Oncology Lysyl oxidase Colorectal cancer Therapeutic targets |
| title | Lysyl oxidase inhibitors in colorectal cancer progression |
| title_full | Lysyl oxidase inhibitors in colorectal cancer progression |
| title_fullStr | Lysyl oxidase inhibitors in colorectal cancer progression |
| title_full_unstemmed | Lysyl oxidase inhibitors in colorectal cancer progression |
| title_short | Lysyl oxidase inhibitors in colorectal cancer progression |
| title_sort | lysyl oxidase inhibitors in colorectal cancer progression |
| topic | Lysyl oxidase Colorectal cancer Therapeutic targets |
| url | http://www.sciencedirect.com/science/article/pii/S1936523324003590 |
| work_keys_str_mv | AT muxianliu lysyloxidaseinhibitorsincolorectalcancerprogression AT jiewang lysyloxidaseinhibitorsincolorectalcancerprogression AT meihongliu lysyloxidaseinhibitorsincolorectalcancerprogression |