Therapeutic alternatives for sporotrichosis induced by wild-type and non-wild-type Sporothrix schenckii through in vitro and in vivo assessment of enilconazole, isavuconazole, posaconazole, and terbinafine

Therapeutic alternatives for sporotrichosis induced by wild-type and non-wild-type Sporothrix schenckii through in vitro and in vivo assessment of enilconazole, isavuconazole, posaconazole, and terbinafine

Abstract This study explores the effectiveness of various antifungal drugs in treating sporotrichosis caused by Sporothrix schenckii, especially in non-wild-type (non-WT) strains. The drugs tested include enilconazole (ENIL), isavuconazole (ISA), posaconazole (POS), terbinafine (TER), and itraconazo...

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Bibliographic Details
Main Authors: Vasurom Aroonvuthiphong, Norasuthi Bangphoomi
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Sporothrix schenckii.
Sporotrichosis
Antifungals
Itraconazole nonwild-type
Galleria mellonella model
Online Access:https://doi.org/10.1038/s41598-025-87711-3
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https://doi.org/10.1038/s41598-025-87711-3

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