Primary pancreas NTRK-rearranged neoplasm harboring an EVT6::NTRK3 fusion with a sclerosing epithelioid fibrosarcoma morphology: a case report and comprehensive review of the literature

Primary pancreas NTRK-rearranged neoplasm harboring an EVT6::NTRK3 fusion with a sclerosing epithelioid fibrosarcoma morphology: a case report and comprehensive review of the literature

NTRK-rearranged spindle cell neoplasms (NTRK-RSCNs) are an emerging soft tissue tumor entity characterized by NTRK gene fusions, occurring predominantly in the extremities of children and young adults. The diagnosis of this tumor is challenging due to its nonspecific and highly variable morphology....

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Bibliographic Details
Main Authors: Xin Wu, Dujuan Li, Fangfang Fu, Lifei Lian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
NTRK-rearranged spindle cell neoplasms
pancreas
sclerosing epithelioid fibrosarcoma-like pattern
NTRK rearrangement
EVT6::NTRK3
pan-TRK immunohistochemistry
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1526281/full
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