Rotating antibiotics selects optimally against antibiotic resistance, in theory

The purpose of this paper is to use mathematical models to investigate the claim made in the medical literature over a decade ago that the routine rotation of antibiotics in an intensive care unit (ICU) will select against the evolution and spread of antibiotic-resistant pathogens. In contrast, pr...

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Bibliographic Details
Main Authors: Robert E. Beardmore, Rafael Peña-Miller
Format: Article
Language:English
Published: AIMS Press 2010-05-01
Series:Mathematical Biosciences and Engineering
Subjects:
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2010.7.527
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