Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence
The modern lifestyle has a negative impact on health. It is usually accompanied by increased stress levels and lower physical activity, which interferes with body homeostasis. Diabetes mellitus is a relatively common metabolic disorder with increasing prevalence globally, associated with various ris...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/7796727 |
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| _version_ | 1832556500548059136 |
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| author | Habib Yaribeygi Mina Maleki Thozhukat Sathyapalan Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_facet | Habib Yaribeygi Mina Maleki Thozhukat Sathyapalan Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_sort | Habib Yaribeygi |
| collection | DOAJ |
| description | The modern lifestyle has a negative impact on health. It is usually accompanied by increased stress levels and lower physical activity, which interferes with body homeostasis. Diabetes mellitus is a relatively common metabolic disorder with increasing prevalence globally, associated with various risk factors, including lower physical activity and a sedentary lifestyle. It has been shown that sedentary behavior increases the risk of insulin resistance, but the intermediate molecular mechanisms are not fully understood. In this mechanistic review, we explore the possible interactions between physical inactivity and insulin resistance to help better understand the pathophysiology of physical inactivity-dependent insulin resistance and finding novel interventions against these deleterious pathways. |
| format | Article |
| id | doaj-art-c9dcbaab063c4bdbb23f750492600a9f |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c9dcbaab063c4bdbb23f750492600a9f2025-02-03T05:45:20ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/77967277796727Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical EvidenceHabib Yaribeygi0Mina Maleki1Thozhukat Sathyapalan2Tannaz Jamialahmadi3Amirhossein Sahebkar4Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IranUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranAcademic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, UKDepartment of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, IranBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranThe modern lifestyle has a negative impact on health. It is usually accompanied by increased stress levels and lower physical activity, which interferes with body homeostasis. Diabetes mellitus is a relatively common metabolic disorder with increasing prevalence globally, associated with various risk factors, including lower physical activity and a sedentary lifestyle. It has been shown that sedentary behavior increases the risk of insulin resistance, but the intermediate molecular mechanisms are not fully understood. In this mechanistic review, we explore the possible interactions between physical inactivity and insulin resistance to help better understand the pathophysiology of physical inactivity-dependent insulin resistance and finding novel interventions against these deleterious pathways.http://dx.doi.org/10.1155/2021/7796727 |
| spellingShingle | Habib Yaribeygi Mina Maleki Thozhukat Sathyapalan Tannaz Jamialahmadi Amirhossein Sahebkar Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence Journal of Diabetes Research |
| title | Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence |
| title_full | Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence |
| title_fullStr | Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence |
| title_full_unstemmed | Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence |
| title_short | Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence |
| title_sort | pathophysiology of physical inactivity dependent insulin resistance a theoretical mechanistic review emphasizing clinical evidence |
| url | http://dx.doi.org/10.1155/2021/7796727 |
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