GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action

GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action

Metabolic dysfunction–associated steatotic liver disease has emerged as a leading global cause of chronic liver disease. Our recent translational investigations have shown that the STE20-type kinases comprising the GCKIII subfamily—MST3, STK25, and MST4—associate with hepatic lipid droplets and regu...

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Main Authors: Emmelie Cansby, Mara Caputo, Emma Andersson, Rasool Saghaleyni, Marcus Henricsson, Ying Xia, Bernice Asiedu, Matthias Blüher, L. Thomas Svensson, Andrew J. Hoy, Margit Mahlapuu
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Lipid Research
Subjects:
MASLD
MASH
lipid droplets
liver
lipotoxicity
lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524001743
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