K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity

K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity

Abstract Background The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in T helper (Th) cell differentiation and autoimmunity is unknown. Th17 cells are believed to play a pivotal role in the development and pathogenesis of autoimmune diseases. Ne...

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Main Authors: Qiuming Zeng, Hui Guo, Na Tang, Pranav S. Renavikar, Nitin J. Karandikar, Amy E. Lovett-Racke, Michael K. Racke, Chengkai Yan, Rong Tang, Sushmita Sinha, Krishnendu Ghosh, Jeremy P. Ryal, Song Ouyang, Min Chen, Foued Amari, Coppola Vincenzo, R. Marshall Pope, Yalan Li, Huan Yang, Wallace Y. Langdon, Jian Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Biomedical Science
Subjects:
Nedd4
HECT E3 ubiquitin ligase
T helper cell 17
RORγt
K27 polyubiquitination
Experimental autoimmune encephalitis
Online Access:https://doi.org/10.1186/s12929-025-01120-2
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