Ante-mortem cognitive trajectories associated with Aβ and tau biomarker profiles in older adults with cerebrovascular disease: a longitudinal cohort study

Ante-mortem cognitive trajectories associated with Aβ and tau biomarker profiles in older adults with cerebrovascular disease: a longitudinal cohort study

Abstract Background Beta-amyloid (Aβ) plaques and tau tangles are pathological hallmarks of Alzheimer’s disease (AD); however, autopsy studies reveal that most older adults also present with cerebrovascular disease (CVD) markers. It remains unclear how Aβ and tau relate to cognition in the context o...

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Bibliographic Details
Main Authors: Emily Rosenich, Yen Ying Lim, on behalf of the National Alzheimer’s Coordinating Center
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Cognition
Beta-amyloid
Tau
Cerebrovascular disease
Online Access:https://doi.org/10.1186/s13195-025-01776-w
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