GSK-3𝜷: A Bifunctional Role in Cell Death Pathways
Although glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional kinase is presently known to be a key regulator of a wide range of cellular functions. GSK-3β is involved in modulating a va...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/930710 |
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| _version_ | 1832564292763779072 |
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| author | Keith M. Jacobs Sandeep R. Bhave Daniel J. Ferraro Jerry J. Jaboin Dennis E. Hallahan Dinesh Thotala |
| author_facet | Keith M. Jacobs Sandeep R. Bhave Daniel J. Ferraro Jerry J. Jaboin Dennis E. Hallahan Dinesh Thotala |
| author_sort | Keith M. Jacobs |
| collection | DOAJ |
| description | Although glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional kinase is presently known to be a key regulator of a wide range of cellular functions. GSK-3β is involved in modulating a variety of functions including cell signaling, growth metabolism, and various transcription factors that determine the survival or death of the organism. Secondary to the role of GSK-3β in various diseases including Alzheimer’s disease, inflammation, diabetes, and cancer, small molecule inhibitors of GSK-3β are gaining significant attention. This paper is primarily focused on addressing the bifunctional or conflicting roles of GSK-3β in both the promotion of cell survival and of apoptosis. GSK-3β has emerged as an important molecular target for drug development. |
| format | Article |
| id | doaj-art-c994799d899d4509913a04d36ffc0e8c |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-c994799d899d4509913a04d36ffc0e8c2025-02-03T01:11:21ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/930710930710GSK-3𝜷: A Bifunctional Role in Cell Death PathwaysKeith M. Jacobs0Sandeep R. Bhave1Daniel J. Ferraro2Jerry J. Jaboin3Dennis E. Hallahan4Dinesh Thotala5Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO 63108, USASchool of Medcine, Washington University in St. Louis, St. Louis, MO 63108, USADepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, MO 63108, USADepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, MO 63108, USADepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, MO 63108, USADepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, MO 63108, USAAlthough glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional kinase is presently known to be a key regulator of a wide range of cellular functions. GSK-3β is involved in modulating a variety of functions including cell signaling, growth metabolism, and various transcription factors that determine the survival or death of the organism. Secondary to the role of GSK-3β in various diseases including Alzheimer’s disease, inflammation, diabetes, and cancer, small molecule inhibitors of GSK-3β are gaining significant attention. This paper is primarily focused on addressing the bifunctional or conflicting roles of GSK-3β in both the promotion of cell survival and of apoptosis. GSK-3β has emerged as an important molecular target for drug development.http://dx.doi.org/10.1155/2012/930710 |
| spellingShingle | Keith M. Jacobs Sandeep R. Bhave Daniel J. Ferraro Jerry J. Jaboin Dennis E. Hallahan Dinesh Thotala GSK-3𝜷: A Bifunctional Role in Cell Death Pathways International Journal of Cell Biology |
| title | GSK-3𝜷: A Bifunctional Role in Cell Death Pathways |
| title_full | GSK-3𝜷: A Bifunctional Role in Cell Death Pathways |
| title_fullStr | GSK-3𝜷: A Bifunctional Role in Cell Death Pathways |
| title_full_unstemmed | GSK-3𝜷: A Bifunctional Role in Cell Death Pathways |
| title_short | GSK-3𝜷: A Bifunctional Role in Cell Death Pathways |
| title_sort | gsk 3𝜷 a bifunctional role in cell death pathways |
| url | http://dx.doi.org/10.1155/2012/930710 |
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