Two Cases of Ectopic Hamartomatous Thymoma Masquerading as Sarcoma
Ectopic hamartomatous thymoma (EHT) is an extremely rare benign tumor. EHTs are difficult to differentiate from sarcomas, especially synovial sarcomas. We encountered two cases of EHT that were referred from other hospitals because sarcoma was suspected. In these cases, fusion gene detection via pol...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2017/1672919 |
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| author | Takahito Kondo Yukiko Sato Hiroko Tanaka Toru Sasaki Kazuyoshi Kawabata Hiroki Mitani Hiroyuki Yonekawa Hirofumi Fukushima Wataru Shimbashi |
| author_facet | Takahito Kondo Yukiko Sato Hiroko Tanaka Toru Sasaki Kazuyoshi Kawabata Hiroki Mitani Hiroyuki Yonekawa Hirofumi Fukushima Wataru Shimbashi |
| author_sort | Takahito Kondo |
| collection | DOAJ |
| description | Ectopic hamartomatous thymoma (EHT) is an extremely rare benign tumor. EHTs are difficult to differentiate from sarcomas, especially synovial sarcomas. We encountered two cases of EHT that were referred from other hospitals because sarcoma was suspected. In these cases, fusion gene detection via polymerase chain reaction or fluorescence in situ hybridization was useful for differentiating EHT from synovial sarcoma. EHT requires accurate diagnosis before surgery to avoid excessive treatment. Both tumor location and the presence of fat inside the tumor are important imaging findings for EHT, and confirmation of spindle cells, epithelial cells, and mature adipose cells in the tumor is an important pathological finding. It is important to exclude synovial sarcoma from the differential diagnosis via fusion gene analysis. |
| format | Article |
| id | doaj-art-c9694e2d280d4a31a87ff3eac2bdf112 |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-c9694e2d280d4a31a87ff3eac2bdf1122025-02-03T01:30:06ZengWileyCase Reports in Otolaryngology2090-67652090-67732017-01-01201710.1155/2017/16729191672919Two Cases of Ectopic Hamartomatous Thymoma Masquerading as SarcomaTakahito Kondo0Yukiko Sato1Hiroko Tanaka2Toru Sasaki3Kazuyoshi Kawabata4Hiroki Mitani5Hiroyuki Yonekawa6Hirofumi Fukushima7Wataru Shimbashi8Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koutou-ku, Tokyo 135-8550, JapanDepartment of Pathology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koutou-ku, Tokyo 135-8550, JapanDepartment of Diagnostic Imaging, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koutou-ku, Tokyo 135-8550, JapanDepartment of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koutou-ku, Tokyo 135-8550, JapanDepartment of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koutou-ku, Tokyo 135-8550, JapanDepartment of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koutou-ku, Tokyo 135-8550, JapanDepartment of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koutou-ku, Tokyo 135-8550, JapanDepartment of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koutou-ku, Tokyo 135-8550, JapanDepartment of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koutou-ku, Tokyo 135-8550, JapanEctopic hamartomatous thymoma (EHT) is an extremely rare benign tumor. EHTs are difficult to differentiate from sarcomas, especially synovial sarcomas. We encountered two cases of EHT that were referred from other hospitals because sarcoma was suspected. In these cases, fusion gene detection via polymerase chain reaction or fluorescence in situ hybridization was useful for differentiating EHT from synovial sarcoma. EHT requires accurate diagnosis before surgery to avoid excessive treatment. Both tumor location and the presence of fat inside the tumor are important imaging findings for EHT, and confirmation of spindle cells, epithelial cells, and mature adipose cells in the tumor is an important pathological finding. It is important to exclude synovial sarcoma from the differential diagnosis via fusion gene analysis.http://dx.doi.org/10.1155/2017/1672919 |
| spellingShingle | Takahito Kondo Yukiko Sato Hiroko Tanaka Toru Sasaki Kazuyoshi Kawabata Hiroki Mitani Hiroyuki Yonekawa Hirofumi Fukushima Wataru Shimbashi Two Cases of Ectopic Hamartomatous Thymoma Masquerading as Sarcoma Case Reports in Otolaryngology |
| title | Two Cases of Ectopic Hamartomatous Thymoma Masquerading as Sarcoma |
| title_full | Two Cases of Ectopic Hamartomatous Thymoma Masquerading as Sarcoma |
| title_fullStr | Two Cases of Ectopic Hamartomatous Thymoma Masquerading as Sarcoma |
| title_full_unstemmed | Two Cases of Ectopic Hamartomatous Thymoma Masquerading as Sarcoma |
| title_short | Two Cases of Ectopic Hamartomatous Thymoma Masquerading as Sarcoma |
| title_sort | two cases of ectopic hamartomatous thymoma masquerading as sarcoma |
| url | http://dx.doi.org/10.1155/2017/1672919 |
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