Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients

ObjectivesTo assess the pharmacokinetics and pharmacodynamics of imipenem in a retrospective cohort of hospitalized Chinese older patients.MethodsA population pharmacokinetic (PPK) model was constructed utilizing a nonlinear mixed-effects modeling approach. The final model underwent evaluation throu...

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Bibliographic Details
Main Authors: Jing Wang, Qiu Fang, Xuemei Luo, Lu Jin, Huaijun Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1524272/full
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