Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway

Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway

Abstract Coenzyme Q (CoQ) is an electron acceptor for sulfide‐quinone reductase (SQR), the first enzyme of the hydrogen sulfide oxidation pathway. Here, we show that lack of CoQ in human skin fibroblasts causes impairment of hydrogen sulfide oxidation, proportional to the residual levels of CoQ. Bio...

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Main Authors: Marcello Ziosi, Ivano Di Meo, Giulio Kleiner, Xing‐Huang Gao, Emanuele Barca, Maria J Sanchez‐Quintero, Saba Tadesse, Hongfeng Jiang, Changhong Qiao, Richard J Rodenburg, Emmanuel Scalais, Markus Schuelke, Belinda Willard, Maria Hatzoglou, Valeria Tiranti, Catarina M Quinzii
Format: Article
Language:English
Published: Springer Nature 2016-11-01
Series:EMBO Molecular Medicine
Subjects:
coenzyme Q
CoQ10
Pdss2
SQR
sulfides
Online Access:https://doi.org/10.15252/emmm.201606356
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https://doi.org/10.15252/emmm.201606356

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