Exploring ID4 as a driver of aggression and a therapeutic target in triple-negative breast cancer

Abstract Basal-like breast cancer (BLBC) is an aggressive subtype with poor prognosis and limited treatment options. The Inhibitor of Differentiation 4 (ID4) protein is frequently overexpressed in BLBC, yet its role in tumor progression remains unclear. Here, we used CRISPR–Cas9-mediated ID4 knockou...

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Bibliographic Details
Main Authors: C. Toro, S. Real, S. Laurito, M. T. Branham
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-025-00787-y
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