Interleukin-5 Potentiates Sulfidopeptide Leukotriene Production by Human Eosinophils
Interleukin-5 (IL-5) has been shown to be a selective eosinophil growth and differentiation factor. In the present study, the effect of recombinant human IL-5 on human eosinophil sulfidopeptide leukotriene production was investigated. IL-5 did not affect leukotriene synthesis in unstimulated eosinop...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000098 |
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| Summary: | Interleukin-5 (IL-5) has been shown to be a selective eosinophil
growth and differentiation factor. In the present study, the effect
of recombinant human IL-5 on human eosinophil sulfidopeptide
leukotriene production was investigated. IL-5 did not affect
leukotriene synthesis in unstimulated eosinophils. However, IL-5
potentiated leukotriene synthesis by eosinophils stimulated with
serum treated zymosan (STZ) or the calcium ionophore A23187 by
69% and 135%, respectively. The priming effect of IL-5
was dose dependent, with significant stimulation occurring at 1 000
U/ml for STZ and 100-1 000 U/ml for A23187. Pre-incubation with IL-5
did not increase leukotriene synthesis further. |
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| ISSN: | 0962-9351 1466-1861 |