The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis
There is growing evidence that inflammation may be one of the causal factors of osteoporosis. Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorpt...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2012/142702 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560490843209728 |
|---|---|
| author | A. S. Nazrun M. Norazlina M. Norliza S. Ima Nirwana |
| author_facet | A. S. Nazrun M. Norazlina M. Norliza S. Ima Nirwana |
| author_sort | A. S. Nazrun |
| collection | DOAJ |
| description | There is growing evidence that inflammation may be one of the causal factors of osteoporosis. Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorptive activity. Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6. Free radicals are known to activate transcription factor NFκB which leads to the production of bone resorbing cytokines. Vitamin E, a potent antioxidant, may be able to neutralise free radicals before they could activate NFκB, therefore suppressing cytokine production and osteoporosis. Vitamin E has also been shown to inhibit COX-2, the enzyme involved in inflammatory reactions. Of the two types of vitamin E studied, tocotrienol seemed to be better than tocopherol in terms of its ability to suppress bone-resorbing cytokines. |
| format | Article |
| id | doaj-art-c8ad91e4067c4fbf9530d6b57b4fe6e3 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-c8ad91e4067c4fbf9530d6b57b4fe6e32025-02-03T01:27:28ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422012-01-01201210.1155/2012/142702142702The Anti-Inflammatory Role of Vitamin E in Prevention of OsteoporosisA. S. Nazrun0M. Norazlina1M. Norliza2S. Ima Nirwana3Department of Pharmacology, Faculty of Medicine, The National University of Malaysia, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, The National University of Malaysia, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, The National University of Malaysia, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, The National University of Malaysia, 50300 Kuala Lumpur, MalaysiaThere is growing evidence that inflammation may be one of the causal factors of osteoporosis. Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorptive activity. Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6. Free radicals are known to activate transcription factor NFκB which leads to the production of bone resorbing cytokines. Vitamin E, a potent antioxidant, may be able to neutralise free radicals before they could activate NFκB, therefore suppressing cytokine production and osteoporosis. Vitamin E has also been shown to inhibit COX-2, the enzyme involved in inflammatory reactions. Of the two types of vitamin E studied, tocotrienol seemed to be better than tocopherol in terms of its ability to suppress bone-resorbing cytokines.http://dx.doi.org/10.1155/2012/142702 |
| spellingShingle | A. S. Nazrun M. Norazlina M. Norliza S. Ima Nirwana The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis Advances in Pharmacological Sciences |
| title | The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis |
| title_full | The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis |
| title_fullStr | The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis |
| title_full_unstemmed | The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis |
| title_short | The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis |
| title_sort | anti inflammatory role of vitamin e in prevention of osteoporosis |
| url | http://dx.doi.org/10.1155/2012/142702 |
| work_keys_str_mv | AT asnazrun theantiinflammatoryroleofvitamineinpreventionofosteoporosis AT mnorazlina theantiinflammatoryroleofvitamineinpreventionofosteoporosis AT mnorliza theantiinflammatoryroleofvitamineinpreventionofosteoporosis AT simanirwana theantiinflammatoryroleofvitamineinpreventionofosteoporosis AT asnazrun antiinflammatoryroleofvitamineinpreventionofosteoporosis AT mnorazlina antiinflammatoryroleofvitamineinpreventionofosteoporosis AT mnorliza antiinflammatoryroleofvitamineinpreventionofosteoporosis AT simanirwana antiinflammatoryroleofvitamineinpreventionofosteoporosis |